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[CAS NO. 106577-39-3] Hederacolchiside A1
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-N6950 |
| Brand: | MCE |
| CAS: | 106577-39-3 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 897.10 |
| Molecular Formula | C47H76O16 |
| SMILES | C[C@]12[C@]3(C([C@@]4([H])[C@](C(O)=O)(CCC(C)(C)C4)CC3)=CC[C@]1([H])[C@@]5([C@@](C(C)([C@@H](O[C@@]6([H])[C@@H]([C@H]([C@@H](O[C@]7([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)CO)CO6)O)O[C@@]8([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O8)O)O)CC5)C)([H])CC2)C)C |
Summary
Hederacolchiside A1, isolated from Pulsatilla chinensis , suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway [1] . Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro [2] .
IC50 & Target
|
PI3K
|
mTOR
|
In Vitro
Hederacolchiside A1 reduces the mitochondrial membrane potential and Bcl-2 protein levels, whereas cleaved caspase-3 was higher
[1]
.
Hederacolchiside A1 effectively inhibits the phosphorylations of phosphatidylinositol 3 kinase (PI3K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR)
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
hederacolchiside A1 (3.0, 4.5, and 6.0 mg/kg, ip) can significantly inhibit the weight of tumor in an H22 xenograft model
[1]
.
Hederacolchiside A1 (3.25, 7.5, and 15.0 mg/kg, ig) can significantly inhibit the weight of tumor in nude mice xenograft tumor models using human breast carcinoma MCF-7 cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL ( 111.47 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.1147 mL | 5.5735 mL | 11.1470 mL |
| 5 mM | 0.2229 mL | 1.1147 mL | 2.2294 mL |
| 10 mM | 0.1115 mL | 0.5574 mL | 1.1147 mL |
References
- [1] Yan-Er Wang, et al. Hederacolchiside A1 suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway. Chinese Herbal Medicines.Volume 10, Issue 2, April 2018, Pages 215-222
- [2] Kang N, et al. Antischistosomal Properties of Hederacolchiside A1 Isolated from . Molecules. 2018 Jun 13;23(6).
Synonyms
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