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[CAS NO. 1067647-43-1] ELOVL6-IN-2
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-12146 |
| Brand: | MCE |
| CAS: | 1067647-43-1 |
Overview
| MDL | MFCD18782631 |
|---|---|
| Molecular Weight | 579.49 |
| Molecular Formula | C28H23F6N3O4 |
| SMILES | O=C1N(C2=CC=CC=C2)C3=C(C(CC(C)(C)C3)=O)C1(C4=C(C)NN(C5=CC=C(OC(F)(F)F)C=C5)C4=O)C(F)(F)F |
Summary
ELOVL6-IN-2 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-2 inhibits mouse ELOVL6 activities, with an IC 50 value of 34 nM [1] .
IC50 & Target
IC50: 34 nM (ELOVL6) [1]
In Vivo
ELOVL6-IN-2 (0.1~1mg/kg; p.o.; 2 hours) potently and dose-proportionally suppresses the elongation index in the liver
[1]
.
ELOVL6-IN-2 (10mg/kg; p.o.; 2 hours) demonstrates highly liver penetrable
[1]
.
ELOVL6-IN-2 (1mg/kg; p.o.; 2~24 hours) exhibits sustained plasma exposure
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Male C57BL/6J mice |
| Dosage: | 0.1~1mg/kg |
| Administration: | P.o |
| Result: | Potently and dose-proportionally suppressed the elongation index in the liver. |
| Animal Model: | Male C57BL/6J mice |
| Dosage: | 10 mg/kg |
| Administration: | P.o |
| Result: | Demonstrated highly liver penetrable. |
| Animal Model: | Male C57BL/6J mice |
| Dosage: | 1 mg/kg |
| Administration: | P.o |
| Result: | Exhibited sustained plasma exposure. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 172.57 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.7257 mL | 8.6283 mL | 17.2566 mL |
| 5 mM | 0.3451 mL | 1.7257 mL | 3.4513 mL |
| 10 mM | 0.1726 mL | 0.8628 mL | 1.7257 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (4.31 mM); Clear solution
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