[CAS NO. 1069858-99-6] ML359
PRODUCTS SPECIFICATIONS [1069858-99-6]
DESCRIPTION [1069858-99-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 417.93 |
| Molecular Formula | C23H28ClNO4 |
| SMILES | O=C(C1(CCN(CC1)CC2=CC=C(C(Cl)=C2)O)CCOC3=CC=CC=C3)OCC |
Summary
IC50 & Target
IC50: 250 nM (protein disulfide isomerase) [1]
In Vitro
ML359 shows no cytotoxicity in three human cell lines (HeLa, HEK293, and HepG2), and some activity in inhibiting platelet aggregation in vitro (25% inhibition at 30 µM) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
ML359 inhibits of thrombus formation in a mouse laser injury model [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 239.27 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3927 mL | 11.9637 mL | 23.9275 mL |
| 5 mM | 0.4785 mL | 2.3927 mL | 4.7855 mL |
| 10 mM | 0.2393 mL | 1.1964 mL | 2.3927 mL |
References
- [1] Khodier C, et, al. Identification of ML359 as a Small Molecule Inhibitor of Protein Disulfide Isomerase. Probe Reports from the NIH Molecular Libraries Program. 2010-2013 Apr 12.
- [2] Bendapudi PK, et, al. ML359, a Small Molecule Inhibitor of Protein Disulfide Isomerase That Prevents Thrombus Formation and Inhibits Oxidoreductase but Not Transnitrosylase Activity. Blood (2014) 124 (21): 2880.