[CAS NO. 1071992-81-8]  SM-433

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PRODUCTS SPECIFICATIONS [1071992-81-8]

Catalog
HY-138059
Brand
MCE
CAS
1071992-81-8

DESCRIPTION [1071992-81-8]

Overview

MDL-
Molecular Weight561.71
Molecular FormulaC32H43N5O4
SMILESO=C([C@@H]1CC[C@@](CCN(C(CC(C)C)=O)C[C@@H]2NC([C@@H](NC)C)=O)([H])N1C2=O)NCC3=CC=CC=C3C4=CC=CC=C4

For research use only. We do not sell to patients.

Summary

SM-433, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs) . SM-433 exhibits strong binding affinity XIAP BIR3 protein with an IC 50 <1 μM (patent WO2008128171A2) [1] .


In Vitro

SM-433 exhibits strong inhibitory activity against MDA-MB -2131 human breast cancer cells and SK-OV-3 ovarian cancer cells (IC 50 s<10 μM, respectively) [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)


Solvent & Solubility

In Vitro:

DMSO : 160 mg/mL ( 284.84 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7803 mL 8.9014 mL 17.8028 mL
5 mM 0.3561 mL 1.7803 mL 3.5606 mL
10 mM 0.1780 mL 0.8901 mL 1.7803 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 4 mg/mL (7.12 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 4 mg/mL (7.12 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 4 mg/mL (7.12 mM); Clear solution

* All of the co-solvents are available by MCE.