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[CAS NO. 107355-45-3] WIN 54954
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-106296 |
| Brand: | MCE |
| CAS: | 107355-45-3 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 383.27 |
| Molecular Formula | C18H20Cl2N2O3 |
| SMILES | ClC1=C(OCCCCCC2=CC(C)=NO2)C(Cl)=CC(C3=NCCO3)=C1 |
Summary
WIN 54954 is an orally active and broad-spectrum antipicornavirus agent. WIN 54954 is effectiveness against human rhinovirus, echovirus 9 and enterovirus infections [1] [2] .
In Vitro
In Vivo
WIN 54954 (2-100 mg/kg; p.o.) protects 50% of the mice from developing paralysis following infection with coxsackievirus A-9 and echovirus-9 at the dose of 2 and 100 mg/kg, respectively [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL ( 260.91 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.6091 mL | 13.0456 mL | 26.0913 mL |
| 5 mM | 0.5218 mL | 2.6091 mL | 5.2183 mL |
| 10 mM | 0.2609 mL | 1.3046 mL | 2.6091 mL |
References
- [1] Woods MG, et, al. In vitro and in vivo activities of WIN 54954, a new broad-spectrum antipicornavirus drug. Antimicrob Agents Chemother. 1989 Dec;33(12):2069-74.
- [2] Fechner H, et, al. Pharmacological and biological antiviral therapeutics for cardiac coxsackievirus infections. Molecules. 2011 Oct 11;16(10):8475-503.
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