[CAS NO. 108-53-2] Isocytosine

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PRODUCTS SPECIFICATIONS [108-53-2]

Catalog

HY-W002272

Brand

MCE

CAS

108-53-2

DESCRIPTION [108-53-2]

Overview

MDL	MFCD00057557
Molecular Weight	111.10
Molecular Formula	C4H5N3O
SMILES	O=C1N=C(N)NC=C1

For research use only. We do not sell to patients.

Summary

Isocytosine is a non-natural nucleobase and an isomer of cytosine. It is used in combination with Isoguanine in studies of unnatural nucleic acid analogues of the normal base pairs in DNA and used as a nucleobase of hachimoji RNA ^[1] ^[2] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 33.33 mg/mL ( 300.00 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	9.0009 mL	45.0045 mL	90.0090 mL
5 mM	1.8002 mL	9.0009 mL	18.0018 mL
10 mM	0.9001 mL	4.5005 mL	9.0009 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (22.50 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (22.50 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

4(1H)-Pyrimidinone, 2-amino-

Isocytosine

2-Amino-4(1H)-pyrimidinone

2-Amino-4-pyrimidone

2-Amino-4-pyrimidinol

2-Amino-4-hydroxypyrimidine

2-Aminouracil

NSC 49118

2-Aminopyrimidin-4(3H)-one

2-Amino-3,4-dihydropyrimidin-4-one

2-Amino-6-hydroxypyrimidine

2-Amino-1H-pyrimidin-4-one

2-Amino-1,4-dihydropyrimidin-4-one

2-Amino-1H-pyrimidin-6-one