[CAS NO. 108237-91-8] RCGD423
PRODUCTS SPECIFICATIONS [108237-91-8]
DESCRIPTION [108237-91-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 331.23 |
| Molecular Formula | C15H11BrN2S |
| SMILES | BrC1=CC=C(C=C1)NC2=NC(C3=CC=CC=C3)=CS2 |
1 Publications Citing Use of MCE
Summary
RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair.
IC50 & Target
|
IL6-beta |
In Vitro
RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
RCGD423 greatly reduces chondrocyte hypertrophy, loss and degeneration while increasing chondrocyte proliferation beyond that observed in response to injury in a rat partial meniscectomy model. Moreover, RCGD 423 improves cartilage healing in a rat full-thickness osteochondral defect model, increasing proliferation of mesenchymal cells in the defect and also inhibiting breakdown of cartilage matrix in de novo generated cartilage [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 125 mg/mL ( 377.38 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.0191 mL | 15.0953 mL | 30.1905 mL |
| 5 mM | 0.6038 mL | 3.0191 mL | 6.0381 mL |
| 10 mM | 0.3019 mL | 1.5095 mL | 3.0191 mL |