[CAS NO. 108238-41-1] 3,6-Dihydroxyflavone

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PRODUCTS SPECIFICATIONS [108238-41-1]

Catalog

HY-N8481

Brand

MCE

CAS

108238-41-1

DESCRIPTION [108238-41-1]

Overview

MDL	MFCD00143082
Molecular Weight	254.24
Molecular Formula	C15H10O4
SMILES	O=C1C(O)=C(C2=CC=CC=C2)OC3=CC=C(O)C=C13

For research use only. We do not sell to patients.

Summary

3,6-Dihydroxyflavone is an anti-cancer agent. 3,6-Dihydroxyflavone dose- and time-dependently decreases cell viability and induces apoptosis by activating caspase cascade, cleaving poly (ADP-ribose) polymerase (PARP). 3,6-Dihydroxyflavone increases intracellular oxidative stress and lipid peroxidation ^[1] .

Appearance

Solid

Source

Plants

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 66.67 mg/mL ( 262.23 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9333 mL	19.6665 mL	39.3329 mL
5 mM	0.7867 mL	3.9333 mL	7.8666 mL
10 mM	0.3933 mL	1.9666 mL	3.9333 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (9.83 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Chang H, et al. 3,6-Dihydroxyflavone induces apoptosis in leukemia HL-60 cell via reactive oxygen species-mediated p38 MAPK/JNK pathway. Eur J Pharmacol. 2010;648(1-3):31-38.

Synonyms

4H-1-Benzopyran-4-one, 3,6-dihydroxy-2-phenyl-

Flavone, 3,6-dihydroxy-

3,6-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one

3,6-Dihydroxyflavone

3,6-Dihydroxy-2-phenyl-4H-chromen-4-one

3,6-Dihydroxy-2-phenylchromen-4-one