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[CAS NO. 11078-21-0] Filipin complex
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-N6716 |
| Brand: | MCE |
| CAS: | 11078-21-0 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 654.80 |
| Molecular Formula | C35H58O11(forFilipinIII) |
| SMILES | [Filipin complex] |
4 Publications Citing Use of MCE
Summary
Filipin complex is a potent broad spectrum 28-membered ring pentaene macrolide antifungal antibiotic . Filipin complex is also a highly fluorescent polyene. Filipin complex specifically binds free cholesterol and is well established as a histochemical marker for the detection of unesterified cellular cholesterol . Filipin complex consists of four analogues (Filipins I-IV), with Filipin III (HY-N6718) comprising the bulk (>70%) of the complex [1] [2] [3] .
IC50 & Target
|
Macrolide
|
In Vitro
Appearance
Solid
Source
Streptomyces filipinensis
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 152.72 mM )
Ethanol : 10 mg/mL ( 15.27 mM ; ultrasonic and warming and heat to 60°C)
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.5272 mL | 7.6359 mL | 15.2718 mL |
| 5 mM | 0.3054 mL | 1.5272 mL | 3.0544 mL |
| 10 mM | 0.1527 mL | 0.7636 mL | 1.5272 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (3.82 mM); Clear solution
-
3.
References
- [1] Kelly PM, et al. Separation of the filipin complex by gradient-elution high performance liquid chromatography. J Antibiot (Tokyo). 1985 Apr;38(4):485-9.
- [2] Payero TD, et al. Functional analysis of filipin tailoring genes from reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives. Microb Cell Fact. 2015 Aug 7;14:114.
- [3] Kühnl A, et al. Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibiting Endosomal Escape of Influenza A Virus. mBio. 2018 Jul 24;9(4):e01345-18.
Synonyms
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