[CAS NO. 1111078-63-7] SCD1-IN-1
PRODUCTS SPECIFICATIONS [1111078-63-7]
DESCRIPTION [1111078-63-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 395.37 |
| Molecular Formula | C20H20F3NO4 |
| SMILES | FC(F)(F)C(C=CC=C1)=C1O[C@@H]2CN(CC2)C(COC3=CC=C(C=C3)CO)=O |
Summary
SCD1-IN-1 is a SCD1 inhibitor ( IC 50 : 5.8 nM). SCD1-IN-1 can be used in the research of dermatologic condition [1] .
IC50 & Target
SCD1 [1] .
In Vitro
SCD1-IN-1 (compound I, 6 days) inhibits the SCD1 enzyme in intact human cells, with an IC
50
value of 6.8 nM
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
SCD1-IN-1 (compound I, 1.5% w/v, 25 μL, applied to surfaces of ears) reduces in cholesterol ester (CE) and wax ester (WE) production in hamster ear model [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Hamster ear model [1] |
| Dosage: | 1.5% in a vehicle of propylene glycol/transcutanol/ethanol 20/20/60, w/v, 25 μL. |
| Administration: | Applied to ~3 cm 2 of the ventral surfaces of both the right and left ears, twice daily for 2 weeks. |
| Result: | Resulted in a 62% reduction in CE and an 82% reduction in WE, a mechanism biomarker for sebum production in the hamster model, and a reduction in sebaceous gland size. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References