[CAS NO. 1127442-82-3] IWR-1
PRODUCTS SPECIFICATIONS [1127442-82-3]
DESCRIPTION [1127442-82-3]
Overview
| MDL | MFCD18086875 |
|---|---|
| Molecular Weight | 409.44 |
| Molecular Formula | C25H19N3O3 |
| SMILES | O=C(NC1=C2N=CC=CC2=CC=C1)C3=CC=C(N(C([C@]4([H])[C@](C5)([H])C=C[C@]5([H])[C@]64[H])=O)C6=O)C=C3 |
24 Publications Citing Use of MCE
- [1]Nano Today. 21 September 2022.
- [2]Sci Total Environ. 2022 Feb 25;809:152102.
- [3]Oxid Med Cell Longev. 16 Aug 2021.
- [4]J Genet Genomics. 2022 Nov 29;S1673-8527(22)00250-8.
- [5]Cell Biosci. 2019 Jun 14;9:48.
- [6]FASEB J. 2022 May;36(5):e22316.
- [7]iScience. 2019 Sep 27;19:1248-1259.
- [8]J Agric Food Chem. 2022 Oct 21.
- [9]Cancer Cell Int. 2019 Nov 27;19:314.
- [10]J Orthop Transl. 2020 Mar 28;23:29-37.
- [11]Cell Signal. 2022 Mar 6;110299.
- [12]Neurochem Int. 2022 Jul 6;105389.
- [13]Oncol Rep. 2018 Aug;40(2):877-886.
- [14]Exp Cell Res. 2022 Nov 11;422(1):113416.
- [15]Ann Transl Med. Jan 07, 2022.
- [16]Cell Biol Int. 2017 May;41(5):534-543.
- [17]Aquacul Rep. 2021, 100774.
- [18]Theriogenology. 17 September 2022.
- [19]Ren Fail. 2019 Nov;41(1):159-166.
- [20]Cytotechnology. 2021 Feb 26.
- [21]Research Square Print. September 27th, 2022.
- [22]Research Square Print. September 2nd, 2022.
- [23]Research Square Preprint. 2021 Jun.
- [24]Curr Protoc Cell Biol. 2018 Dec;81(1):e62.
Summary
IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.
IC50 & Target
IC50: 180 nM (Wnt)
In Vitro
Both IWR-1 and XAV939 act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects in vitro. IWR-1 exerts its effect via interaction with Axin, while XAV939 binds TNKS directly [1] . IWR-1 (10 μM) induces stabilization of β-catenin disruption complex. IWR-1 (10 μM) is added to the medium together with MIF, the size of cell colonies is extremely decreased, and that indicates the promoting effect of MIF on NSPC proliferation is inhibited by IWR-1 in any MIF concentration group. 2, 5 and 10 μM of IWR-1 significantly inhibits the proliferation of NSPC dose-dependently. IWR-1 inhibites the promoting effect of MIF on NSPC differentiation to neuron lineage [2] . IWR-1 treatment in the presence of maximal stimulatory dose of FSH (0.5 ng/mL) results in a dose dependent inhibition of the stimulatory effect of FSH with > 75% inhibition observed at the maximal inhibitory dose of IWR-1 (1 µM). IWR-1 treatment partially reverses the FSH-induced inhibition of granulosa cell CARTPT mRNA expression [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 122.12 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4424 mL | 12.2118 mL | 24.4236 mL |
| 5 mM | 0.4885 mL | 2.4424 mL | 4.8847 mL |
| 10 mM | 0.2442 mL | 1.2212 mL | 2.4424 mL |
References
- [1] Lu J, et al. Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg Med Chem Lett. 2009 Jul 15;19(14):3825-7.
- [2] Zhang X, et al. Macrophage migration inhibitory factor promotes proliferation and neuronal differentiation of neural stem/precursor cells through Wnt/β-catenin signal pathway. Int J Biol Sci. 2013 Nov 28;9(10):1108-20.
- [3] Gupta PS, et al. Regulation and Regulatory Role of WNT Signaling in Potentiating FSH Action during Bovine Dominant Follicle Selection. PLoS One. 2014 Jun 17;9(6):e100201.