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[CAS NO. 1135205-94-5] AWL-II-38.3
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-18832 |
| Brand: | MCE |
| CAS: | 1135205-94-5 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 469.42 |
| Molecular Formula | C23H18F3N5O3 |
| SMILES | O=C(C1=CC=NO1)NC2=CC(NC(C3=CC(C(F)(F)F)=CC(N4C=NC(C)=C4)=C3)=O)=CC=C2C |
Summary
In Vitro
AWL-II-38.3 fits to LIMK2 and LIMK1 ATP-binding and substrate-binding pockets [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 66.67 mg/mL ( 142.03 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1303 mL | 10.6514 mL | 21.3029 mL |
| 5 mM | 0.4261 mL | 2.1303 mL | 4.2606 mL |
| 10 mM | 0.2130 mL | 1.0651 mL | 2.1303 mL |
-
1.
References
- [1] Yongmun Choi, et al. Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70.
- [2] Efrat Mashiach-Farkash, et al. Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. Oncotarget. 2012 Jun;3(6):629-39.
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