[CAS NO. 1135219-23-6] ALW-II-49-7

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Catalog:	HY-18833
Brand:	MCE
CAS:	1135219-23-6

Overview

MDL	-
Molecular Weight	414.38
Molecular Formula	C21H17F3N4O2
SMILES	O=C(C1=CC(NC2=CC(C(NC3=CC=CC(C(F)(F)F)=C3)=O)=CC=C2C)=CN=C1)N

For research use only. We do not sell to patients.

Summary

ALW-II-49-7 is a selective EphB2 kinase inhibitor with an EC ₅₀ value of 40 nM in cell ^[1] .

IC50 & Target

EphB2 ^[1]

In Vitro

ALW-II-49-7 (compound 9) exhibits selectivity profile of binding to a set of kinases including b-raf, CSF1R, DDR1, DDR2, EphA2, EphA5, EphA8, EphB1, EphB2, EphB3, Frk, Kit, Lck, p38a, p38b, PDGFRa, PDGFRb, and Raf1 ^[1] .
ALW-II-49-7 (0.01-10 μM; 1 h) inhibits EphB2 tyrosine kinase activity in U87 glioblastoma cells. EphB2 is added in media at 2 μg/mL ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] Choi Y, et al. Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70.

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