[CAS NO. 1139-30-6] Caryophyllene oxide

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PRODUCTS SPECIFICATIONS [1139-30-6]

Catalog

HY-N3544

Brand

MCE

CAS

1139-30-6

DESCRIPTION [1139-30-6]

Overview

MDL	-
Molecular Weight	220.35
Molecular Formula	C15H24O
SMILES	C=C1CC[C@@]2([H])O[C@]2(C)CC[C@@]3([H])C(C)(C)C[C@]13[H]

For research use only. We do not sell to patients.

Summary

Caryophyllene oxide, isolated from from Hymenaea courbaril , possesses analgesic and anti-inflammatory activity ^[1] .

IC50 & Target

Human Endogenous Metabolite

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 453.82 mM ; Need ultrasonic)

H ₂ O : 1 mg/mL ( 4.54 mM ; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.5382 mL	22.6912 mL	45.3823 mL
5 mM	0.9076 mL	4.5382 mL	9.0765 mL
10 mM	0.4538 mL	2.2691 mL	4.5382 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (11.35 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (11.35 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (11.35 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Chavan MJ, et al. Analgesic and anti-inflammatory activity of Caryophyllene oxide from Annona squamosa L. bark. Phytomedicine. 2010 Feb;17(2):149-51.

Synonyms

5-Oxatricyclo[8.2.0.0^4,6]dodecane, 4,12,12-trimethyl-9-methylene-, (1R,4R,6R,10S)-

5-Oxatricyclo[8.2.0.0^4,6]dodecane, 4,12,12-trimethyl-9-methylene-, [1R-(1R*,4R*,6R*,10S*)]-

Caryophyllene oxide

Caryophyllene, epoxide

(1R,4R,6R,10S)-4,12,12-Trimethyl-9-methylene-5-oxatricyclo[8.2.0.0^4,6]dodecane

(-)-β-Caryophyllene epoxide

β-Caryophyllene oxide

β-Caryophyllene epoxide

(-)-Epoxydihydrocaryophyllene

(-)-β-Caryophyllene oxide

4β,5α-Epoxycaryophyllene

(-)-Caryophyllene oxide

trans-Caryophyllene oxide

Caryophyllene 4β,5α-oxide

6,7-Epoxy-3(15)-caryophyllene

Caryophyllene 4β,5α-epoxide