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[CAS NO. 116313-94-1] Nitecapone
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-106842 |
| Brand: | MCE |
| CAS: | 116313-94-1 |
Overview
| MDL | MFCD00866318 |
|---|---|
| Molecular Weight | 265.22 |
| Molecular Formula | C12H11NO6 |
| SMILES | CC(/C(C(C)=O)=C/C1=CC([N+]([O-])=O)=C(O)C(O)=C1)=O |
Summary
In Vitro
Nitecapone (1-100 μM) reducesd GSH (reduced glutathione) depletion induced by ROO - by 11-38% and oxidation to oxidized glutathione (GSSG) by 32-45% [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Nitecapone (30 mg/kg, ip daily for 13 days) reduces development and symptoms of neuropathic pain after spinal nerve ligation in rats [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Eighty-six male Wistar rats, weighing 140-350 g [3] . |
| Dosage: | 30 mg/kg (3.3 mL/kg). |
| Administration: | IP, once daily for 13 days. |
| Result: |
Selectively and specifically inhibits COMT in the peripheral tissues, and to some extent in the CNS for ca. 3 h.
Increased the thresholds for the mechanical stimuli and thus reduced mechanical allodynia. Reduced the number of positive reactions of the ipsilateral paws when compared with the baselines in the nitecapone-pretreated rats. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 188.52 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.7705 mL | 18.8523 mL | 37.7045 mL |
| 5 mM | 0.7541 mL | 3.7705 mL | 7.5409 mL |
| 10 mM | 0.3770 mL | 1.8852 mL | 3.7705 mL |
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1.
References
- [1] Y J Suzuki, et al. Antioxidant properties of nitecapone (OR-462). Free Radic Biol Med. 1992 Nov;13(5):517-25.
- [2] Marcocci L, et al. Nitecapone: a nitric oxide radical scavenger. Biochemistry and Molecular Biology International, 01 Oct 1994, 34(3):531-541.
- [3] Oleg Kambur, et al. Nitecapone reduces development and symptoms of neuropathic pain after spinal nerve ligation in rats. Eur J Pain. 2011 Aug;15(7):732-40.
Synonyms
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