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[CAS NO. 118-42-3] Hydroxychloroquine

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Catalog:	HY-W031727
Brand:	MCE
CAS:	118-42-3

Overview

MDL	MFCD00242707
Molecular Weight	335.87
Molecular Formula	C18H26ClN3O
SMILES	ClC1=CC=C2C(NC(CCCN(CCO)CC)C)=CC=NC2=C1

For research use only. We do not sell to patients.

43 Publications Citing Use of MCE

[1]Nat Biotechnol. 2022 Jul 25.
[2]Nat Biomed Eng. 2021 Nov 8.
[3]Nat Commun. 2022 Jun 14;13(1):3419.
[4]Nat Commun. 2021 Aug 16;12(1):4964.
[5]Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.
[6]Autophagy. 2022 Oct 27.
[7]Autophagy. 2022 Aug 29.
[8]Autophagy. 2022 Jan 6;1-20.
[9]Autophagy. 2021 Sep 15;1-19.
[10]Arthritis Rheumatol. 2022 Sep 3.
[11]ACS Appl Mater Interfaces. 2022 Oct 27.
[12]Theranostics. 2020 Apr 27;10(13):5829-5844.
[13]Cell Rep. 2021 Apr 6;35(1):108959.
[14]J Control Release. 2020 Jan 28;320:304-313.
[15]Clin Chem. 2019 Dec;65(12):1522-1531.
[16]Acta Pharm Sin B. 2021 Dec;11(12):3966-3982.
[17]BMC Med. 2021 Oct 15;19(1):247.
[18]J Autoimmun. 2019 May;99:39-47.
[19]Cell Death Dis. 2020 Apr 24;11(4):279.
[20]Cell Discov. 2020 Mar 18;6:16.
[21]Pharmacol Res. 2021 Apr 30;169:105642.
[22]Clin Sci (Lond). 2019 Aug 14;133(15):1759-1777.
[23]Am J Cancer Res. 2020 Nov 1;10(11):3896-3910.
[24]Acta Pharmacol Sin. 2022 Oct 25.
[25]Acta Pharmacol Sin. 2021 Feb 19.
[26]Biochem Pharmacol. 2021 Dec 28;114904.
[27]Aging. 2021 Mar 10;13(6):8421-8439.
[28]iScience. 30 June 2022, 104690.
[29]Phytomedicine. 2021, 153465.
[30]Sci Rep. 2022 Oct 29;12(1):18259.
[31]Cell Signal. 2019 Feb;54:17-26.
[32]Life Sci. 2021 Oct 26;120095.
[33]Life Sci. 2020 Apr 1;246:117366.
[34]Life Sci. 2020 Feb 15;243:117277.
[35]Front Bioeng Biotechnol. 2020 May 8;8:378.
[36]J Exp Pharmacol. 2022, 14: 353-365.
[37]Eur J Pharmacol. 2 September 2022, 175237.
[38]Biochem Biophys Res Commun. 2 March 2022.
[39]Biochem Biophys Res Commun. 2020 Dec 10;533(3):474-480.
[40]Cell Biochem Funct. 2022 Apr 29.
[41]STAR Protoc. 2022, 3(4): 101859.
[42]Research Square Preprint. 2021 Oct.
[43]Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Transmissores de Hematozoários. 2020 Sep.

Summary

Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 ( TLR7/9 ) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro ^[1] ^[2] ^[3] .

IC50 & Target

Plasmodium

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT03229746	Assiut University	Immune Thrombocytopenia	August 1, 2017	Phase 4
NCT04325893	University Hospital, Angers	Coronavirus	April 1, 2020	Phase 3
NCT04447534	Tanta University	COVID	June 23, 2020	Phase 3
NCT04554979	Cairo University	Covid19\|Diarrhea	June 1, 2020
NCT04363203	Salomeh Keyhani MD\|San Francisco VA Health Care System	SARS-CoV-2\|COVID-19	April 30, 2020	Phase 3
NCT02026232	Washington University School of Medicine	Type 2 Diabetes Mellitus	March 2012	Not Applicable
NCT04593758	Cornerstone Pharmaceuticals	Sarcoma, Clear Cell	September 1, 2021	Phase 1\|Phase 2
NCT03598595	M.D. Anderson Cancer Center\|National Cancer Institute (NCI)	Recurrent Osteosarcoma\|Refractory Osteosarcoma	January 28, 2019	Phase 1\|Phase 2
NCT04352933	Cambridge University Hospitals NHS Foundation Trust	COVID-19	May 11, 2020	Phase 3
NCT04355052	Sheba Medical Center	COVID - 19	April 11, 2020	Phase 3
NCT04323631	Rambam Health Care Campus\|Rabin Medical Center	COVID-19	April 30, 2020	Early Phase 1
NCT01148043	Maasstad Hospital	Osteoarthritis	July 2010	Phase 3
NCT04605588	Rutgers, The State University of New Jersey\|SynaVir	SARS-CoV Infection\|Covid19	December 2, 2020	Phase 2
NCT02257424	Abramson Cancer Center of the University of Pennsylvania	Advanced BRAF Mutant Melanoma	October 2014	Phase 1\|Phase 2
NCT04911816	West Virginia University	Adenocarcinoma of the Pancreas	July 16, 2021	Phase 1\|Phase 2
NCT04366089	Roberto Poscia MD, PhD\|Azienda Policlinico Umberto I	COVID\|SARS-CoV 2\|Pneumonia, Viral\|Coronavirus Infection	March 26, 2020	Phase 2
NCT04411433	Ministry of Health, Turkey\|Hacettepe University, Faculty of Medicine\|Prof. Dr. Cemil Tasc?oglu Education and Research Hospital Organization\|Umraniye Education and Research Hospital\|SB Istanbul Education and Research Hospital\|Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey\|Tepecik Training and Research Hospital\|Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine\|Ankara University\|Ankara City Hospital Bilkent\|Ankara Training and Research Hospital\|Ege University Hospital (Application and Research Center)\|Kocaeli Derince Education and Research Hospital\|Istanbul University\|Kayseri City Hospital	Sars-CoV2\|COVID-19	May 8, 2020	Phase 3
NCT04389320	Assiut University	Rheumatoid Arthritis	March 15, 2020
NCT02475915	South East Asia Research Collaboration with Hawaii\|The Thai Red Cross AIDS Research Centre\|Cooper Human Systems	Acute HIV Infection	January 2015	Phase 1\|Phase 2
NCT02648464	Helsinki University Central Hospital\|Finnish Foundation for Cardiovascular Research\|Orion Corporation, Orion Pharma\|Aarne Koskelo Foundation\|Finnish Cultural Foundation	Myocardial Infarction\|Acute Coronary Syndrome\|Inflammation\|Hydroxychloroquine\|Antirheumatic Agents\|Cardiovascular Diseases	February 1, 2016	Phase 4
NCT00486603	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins\|National Cancer Institute (NCI)	Brain and Central Nervous System Tumors	October 29, 2007	Phase 1\|Phase 2
NCT04361461	Apsen Farmaceutica S.A.\|Federal University of São Paulo	Coronavirus Infections\|SARS-CoV 2\|SARS (Severe Acute Respiratory Syndrome)\|Pulmonary Disease	April 30, 2020	Phase 3
NCT04459702	ProgenaBiome\|Big Corona Ltd.	COVID\|COVID-19\|Corona Virus Infection\|Coronavirus Infection\|Coronavirus Sars-Associated as Cause of Disease Classified Elsewhere\|Coronavirus-19\|SARS-CoV 2\|SARS Pneumonia	July 2020	Phase 2
NCT04372017	Sanford Health	COVID-19\|SARS-CoV 2	May 14, 2020	Phase 3
NCT02644499	Jawaharlal Institute of Postgraduate Medical Education & Research	Rheumatoid Arthritis	December 31, 2015	Phase 4
NCT02942381	Peking University First Hospital	IgA Patients\|Hydroxychloroquine	September 13, 2016	Phase 2
NCT01760421	National Taiwan University Hospital	Hashimoto Thyroiditis	October 2011	Not Applicable
NCT04351919	Abderrahmane Mami Hospital\|Eshmoun Clinical Research Center\|Dacima Consulting	Patients With COVID19	May 5, 2020	Phase 4
NCT05024006	University of the Philippines	Covid19	April 23, 2020	Not Applicable
NCT00786682	University of Medicine and Dentistry of New Jersey\|National Cancer Institute (NCI)\|Rutgers, The State University of New Jersey	Prostate Cancer	December 2008	Phase 2
NCT02414776	Western Regional Medical Center	Estrogen Receptor Positive Breast Cancer	July 2014	Phase 1
NCT03687905	Tanta University	Proliferative Nephritis\|Chloroquine Retinopathy	September 18, 2018
NCT04380818	Grupo de Investigación Clínica en Oncología Radioterapia\|Hospital Universitario Madrid Sanchinarro\|Hospital del Mar\|Hospital Universitari Sant Joan de Reus	Pneumonia, Viral	June 5, 2020	Not Applicable
NCT05083780	Changhoon Yoo\|Oncocross Co. Ltd.\|CytoGen, Inc.\|Asan Medical Center	Pancreatic Cancer	November 30, 2021	Phase 1
NCT03929211	Wake Forest University Health Sciences\|National Cancer Institute (NCI)	Myelodysplastic Syndromes\|Progressive Disease	May 2021	Phase 1\|Phase 2
NCT04351516	University Hospital Tuebingen	SARS-CoV 2\|COVID-19	April 21, 2020	Phase 2\|Phase 3
NCT04316169	Medical College of Wisconsin	Solid Tumor\|Advanced Breast Cancer	October 21, 2021	Phase 1
NCT00765765	University of Medicine and Dentistry of New Jersey\|National Cancer Institute (NCI)\|Rutgers, The State University of New Jersey	Breast Cancer	February 2009	Phase 1\|Phase 2
NCT03774472	M.D. Anderson Cancer Center	Anatomic Stage I Breast Cancer AJCC v8\|Anatomic Stage IA Breast Cancer AJCC v8\|Anatomic Stage IB Breast Cancer AJCC v8\|Anatomic Stage II Breast Cancer AJCC v8\|Anatomic Stage IIA Breast Cancer AJCC v8\|Anatomic Stage IIB Breast Cancer AJCC v8\|Anatomic Stage III Breast Cancer AJCC v8\|Anatomic Stage IIIA Breast Cancer AJCC v8\|Anatomic Stage IIIB Breast Cancer AJCC v8\|Anatomic Stage IIIC Breast Cancer AJCC v8\|Anatomic Stage IV Breast Cancer AJCC v8\|Prognostic Stage I Breast Cancer AJCC v8\|Prognostic Stage IA Breast Cancer AJCC v8\|Prognostic Stage IB Breast Cancer AJCC v8\|Prognostic Stage IIA Breast Cancer AJCC v8\|Prognostic Stage IIB Breast Cancer AJCC v8\|Prognostic Stage III Breast Cancer AJCC v8\|Prognostic Stage IIIA Breast Cancer AJCC v8\|Prognostic Stage IIIB Breast Cancer AJCC v8\|Prognostic Stage IIIC Breast Cancer AJCC v8\|Prognostic Stage IV Breast Cancer AJCC v8	August 20, 2018	Phase 1\|Phase 2
NCT04384458	Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara	Coronavirus Infections	July 20, 2020	Not Applicable
NCT04715295	Yaounde Central Hospital	COVID-19	October 5, 2020	Phase 4
NCT04347889	Stony Brook University	Covid-19	April 20, 2020	Phase 2
NCT04345692	Queen´s Medical Center	COVID-19	March 26, 2020	Phase 3
NCT04365582	Groupe Hospitalier Paris Saint Joseph	COVID	May 7, 2020	Phase 3
NCT04523857	Abramson Cancer Center of the University of Pennsylvania	Breast Cancer	November 1, 2021	Phase 2
NCT01551069	Sanofi	Cutaneous Lupus Erythematosus-Systemic Lupus Erythematosus	March 2012	Phase 3
NCT04328285	Centre Hospitalier Universitaire de Saint Etienne\|Institut Pasteur	COVID-19	April 14, 2020	Phase 3
NCT03122431	University of Sao Paulo General Hospital\|Fundação de Amparo à Pesquisa do Estado de São Paulo	Systemic Lupus Erythematosus (SLE)\|Juvenile SLE\|Cutaneous Lupus	June 5, 2017	Phase 4
NCT04315896	National Institute of Respiratory Diseases, Mexico	COVID-19\|Severe Acute Respiratory Syndrome	April 14, 2020	Phase 3
NCT04163107	Norwegian University of Science and Technology\|St. Olavs Hospital\|Oslo University Hospital	Multiple Myeloma	January 7, 2020	Phase 1
NCT04405921	Centre Hôpital Universitaire Farhat Hached	SARS-CoV-2 Pneumonia\|COVID-19	July 2020	Phase 3
NCT04339816	Frantisek Duska, MD, PhD\|Masaryk Hospital Usti nad Labem\|University Hospital Pilsen\|The Faculty Hospital Na Bulovce\|St. Anne´s University Hospital Brno, Czech Republic\|University Hospital, Motol\|General University Hospital, Prague\|University Hospital Olomouc\|Charles University, Czech Republic	COVID-19\|Respiratory Failure	May 13, 2020	Phase 3
NCT01040195	Sanjay Gandhi Postgraduate Institute of Medical Sciences	Seronegative Spondyloarthropathies	June 2009	Phase 3
NCT04652648	Bryn Mawr Hospital\|Sharpe-Strumia Research Foundation\|Bryn Mawr Hospital Foundation\|Cotswold Foundation	Covid19\|Hydroxychloroquine\|Coronavirus Infection\|Transmission\|Prophylaxis	May 27, 2020	Phase 4
NCT04937907	Shanghai Children´s Hospital	Alport Syndrome, X-Linked	September 8, 2021	Phase 2
NCT04364815	University of the Philippines	COVID-19	December 2020	Phase 3
NCT00726596	Rutgers, The State University of New Jersey\|Rutgers Cancer Institute of New Jersey\|National Cancer Institute (NCI)	Prostate Cancer	August 2008	Phase 2
NCT04597775	Regional Center for Disease Control and Prevention, Jordan\|Farhat Hached Hospital, Tunisia\|Fattouma Bourguiba, Tunisia	SARS-CoV Infection	October 27, 2020	Phase 2\|Phase 3
NCT01709578	Sanofi\|Regeneron Pharmaceuticals	Rheumatoid Arthritis	October 2012	Phase 3
NCT04334148	Adrian Hernandez\|Patient-Centered Outcomes Research Institute\|Duke University	COVID-19	April 22, 2020	Phase 3
NCT04360759	University of Cape Town	Covid-19\|HIV	May 1, 2020	Phase 3
NCT04381936	University of Oxford\|UK Research and Innovation\|National Institute for Health Research, United Kingdom\|Wellcome\|Bill and Melinda Gates Foundation\|Department for International Development, United Kingdom\|Health Data Research UK\|Medical Research Council Population Health Research Unit\|NIHR Clinical Trials Unit Support Funding\|NIHR Health Protection Research Unit in Emerging and Zoonotic Infections	Severe Acute Respiratory Syndrome	March 19, 2020	Phase 2\|Phase 3
NCT04389359	Cambridge University Hospitals NHS Foundation Trust\|University of Cambridge	COVID-19	September 2020	Phase 2\|Phase 3
NCT04145297	University of Utah\|BioMed Valley Discoveries, Inc	Gastrointestinal Neoplasms	March 17, 2020	Phase 1
NCT01978184	Nathan Bahary, MD\|University of Pittsburgh	Pancreatic Cancer	November 2013	Phase 2
NCT02466581	Karolinska Institutet	Rheumatoid Arthritis	February 3, 2015	Phase 4
NCT04788355	Universidade do Vale do Sapucai\|Pfizer\|Apsen Farmaceutica S.A.\|Dermadia\|Methodos Laboratory\|Biofarma	Complication	July 1, 2020	Phase 3
NCT04005781	Universitaire Ziekenhuizen KU Leuven	Obesity	October 1, 2019	Phase 4
NCT03180190	Assiut University	Autoimmune Diseases	June 28, 2017
NCT05221320	BioMed Valley Discoveries, Inc	Tumor, Solid\|Gastrointestinal Cancer	May 26, 2022	Phase 2
NCT04420247	Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva	COVID\|COVID-19\|SARS-CoV 2\|Coronavirus\|Corona Virus Infection	April 16, 2020	Phase 3
NCT01132118	Brigham and Women´s Hospital\|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)	Rheumatoid Arthritis\|Insulin Resistance	June 2010	Phase 3
NCT04342169	University of Utah	Coronavirus Infection\|Coronavirus\|Infectious Disease	April 4, 2020	Phase 2
NCT04334928	Plan Nacional sobre el Sida (PNS)\|Effice Servicios Para la Investigacion S.L.	Coronavirus Infection	April 15, 2020	Phase 3
NCT04372082	University Hospital, Lille\|I-site University Lille North Europe	Sars-CoV2	May 2020	Phase 3
NCT01144169	University of Pittsburgh\|National Institutes of Health (NIH)	Renal Cell Carcinoma	October 2010	Phase 1
NCT04331834	Barcelona Institute for Global Health\|Hospital Clinic of Barcelona\|Laboratorios Rubió\|Fundació Institut de Recerca de l´Hospital de la Santa Creu i Sant Pau\|Hospital Plató\|Hospital de Granollers	COVID-19	April 3, 2020	Phase 3
NCT00809237	National University Hospital, Singapore\|Massachusetts General Hospital\|AstraZeneca	Non-small Cell Lung Cancer	November 2008	Phase 1\|Phase 2
NCT01783106	Royal Liverpool University Hospital\|National Association for Colitis and Crohn´s Disease\|National Institute for Health Research, United Kingdom	Crohn´s Disease	February 1, 2014	Phase 2
NCT05113004	Assistance Publique - Hôpitaux de Paris	Primary Sjögren´s Syndrome (pSS)	January 20, 2022	Phase 2
NCT05016297	Peking Union Medical College Hospital\|Eli Lilly and Company	Sjogren´s Syndrome	July 14, 2022	Phase 2
NCT01326533	University of Pittsburgh\|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	Pre-diabetes	March 2011	Phase 4
NCT04358068	National Institute of Allergy and Infectious Diseases (NIAID)\|Teva Pharmaceutical Industries, Ltd.	COVID-19\|SARS-CoV 2	May 13, 2020	Phase 2
NCT05576896	Northwestern University\|National Cancer Institute (NCI)	Stage IV Colorectal Cancer Positive for BRAF V600E Mutation\|Colorectal Cancer\|Colorectal Cancer Stage IV	October 10, 2022	Phase 2
NCT02057250	Sanofi\|Regeneron Pharmaceuticals	RA	March 2014	Phase 3
NCT04344457	Perseverance Research Center, LLC\|Athena Medical Group	COVID-19	April 16, 2020	Phase 1\|Phase 2
NCT04341493	Hugo Mendieta Zeron\|Materno-Perinatal Hospital of the State of Mexico	Coronavirus Infection	April 6, 2020	Phase 4
NCT05013463	University of Calgary	Multiple Sclerosis, Secondary Progressive	October 1, 2021	Phase 2
NCT04370782	St. Francis Hospital, New York	COVID-19	April 28, 2020	Phase 4
NCT04350450	Montefiore Medical Center	COVID\|Coronavirus\|COVID-19	April 2020	Phase 2
NCT04120883	University of Michigan\|Cures Within Reach	Retinitis Pigmentosa	February 25, 2020	Phase 1\|Phase 2
NCT04341727	Washington University School of Medicine	Coronavirus Infection	April 4, 2020	Phase 3
NCT02351752	LLiu\|Peking University First Hospital	Primary IgA Nephropathy	January 2015	Phase 4
NCT01687179	Brigham and Women´s Hospital\|National Heart, Lung, and Blood Institute (NHLBI)	Lymphangioleiomyomatosis	September 2012	Phase 1
NCT01067417	Medical Research Council\|Wellcome Trust	HIV Infections	June 2008	Phase 2
NCT01023737	Sukeshi Patel\|Merck Sharp & Dohme LLC\|The University of Texas Health Science Center at San Antonio	Malignant Solid Tumour	November 2009	Phase 1
NCT05311813	Beni-Suef University	COVID-19 Pandemic	June 1, 2021	Not Applicable
NCT04381988	Memorial Sloan Kettering Cancer Center	COVID-19\|Cancer	May 7, 2020	Phase 2
NCT04397328	Lawson Health Research Institute	COVID-19	May 19, 2020	Phase 3
NCT04007562	Assistance Publique - Hôpitaux de Paris	LIPIN1 Deficiency	July 2019
NCT04461353	Pulmoquine Therapeutics, Inc\|Rockefeller University	Severe Acute Respiratory Syndrome Coronavirus 2	June 25, 2020	Phase 1
NCT02079077	University of Manitoba\|University of Nairobi	HIV	April 2014	Not Applicable
NCT04334382	Intermountain Health Care, Inc.\|University of Utah\|Utah Department of Health	COVID-19	April 2, 2020	Phase 3
NCT03165136	University Hospital, Brest	Recurrent Miscarriage\|First Trimester Abortion	December 4, 2017	Phase 3
NCT01073852	Vanderbilt University	Chronic Urticaria	June 2011	Not Applicable
NCT04392128	Institut de cancérologie Strasbourg Europe	COVID19\|Hematologic Malignancy	September 2, 2020	Phase 2
NCT02874287	First Affiliated Hospital Xi´an Jiaotong University	Coronary Artery Disease	October 8, 2017	Phase 4
NCT04668469	Benha University	Covid19	June 8, 2020	Not Applicable
NCT04348474	Azidus Brasil	Covid-19	April 20, 2020	Early Phase 1
NCT03030118	Milton S. Hershey Medical Center\|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)	Systemic Lupus Erythematosus	December 28, 2017	Phase 2
NCT00405275	US Department of Veterans Affairs\|Canadian Institutes of Health Research (CIHR)\|Rheumatoid Arthritis Investigational Network (RAIN)\|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)\|VA Office of Research and Development	Rheumatoid Arthritis	July 2007	Not Applicable
NCT04342221	University Hospital Tuebingen\|Robert Bosch Medical Center\|Universitätsklinikum Hamburg-Eppendorf\|Bernhard Nocht Institute for Tropical Medicine	COVID-19, Hydroxychloroquine Sulfate	March 29, 2020	Phase 3
NCT04384380	Taoyuan General Hospital\|Center for Drug Evaluation, Taiwan\|Centers for Disease Control, Taiwan\|Taiwan Food and Drug Administration\|National Health Research Institutes, Taiwan	Coronavirus Infection	April 1, 2020	Not Applicable
NCT01784523	Hospital for Special Surgery, New York\|AntiPhospholipid Syndrome Alliance For Clinical Trials and InternatiOnal Networking\|The New York Community Trust	Antiphospholipid Syndrome	February 2013	Phase 3
NCT05247554	Assistance Publique - Hôpitaux de Paris	Pulmonary Sarcoidosis	March 1, 2022	Phase 3
NCT00176982	Hordinsky, Maria K., MD\|University of Minnesota	Alopecia Areata	April 2002	Phase 4
NCT01601028	Seoul National University Hospital	Autoimmune Diseases\|Sjogren´s Syndrome\|Dry Eye	July 2011	Phase 3
NCT03449758	Sanofi\|Regeneron Pharmaceuticals	Rheumatoid Arthritis	March 5, 2018	Phase 4
NCT02765594	Peking Union Medical College Hospital	Primary IgA Nephropathy	June 2016	Phase 4
NCT01828476	Rutgers, The State University of New Jersey\|Rutgers Cancer Institute of New Jersey\|National Cancer Institute (NCI)\|AbbVie	Prostate Cancer	June 2013	Phase 2
NCT01649947	Rutgers, The State University of New Jersey\|National Cancer Institute (NCI)\|Rutgers Cancer Institute of New Jersey	Non-small Cell Lung Cancer\|Advanced Non-small Cell Lung Cancer\|Recurrent Non-small Cell Lung Cancer	December 23, 2011	Phase 2
NCT04329572	Azidus Brasil	COVID-19	April 23, 2020	Early Phase 1
NCT01768572	Sanofi\|Regeneron Pharmaceuticals	Rheumatoid Arthritis	March 2013	Phase 3
NCT03283566	The Cleveland Clinic\|Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)\|Stanford University	Chronic Pancreatitis\|Insulin Dependent Diabetes	October 3, 2017	Phase 2
NCT04410562	Barcelona Institute for Global Health\|Hospital Clinic of Barcelona\|Fundació Institut de Recerca de l´Hospital de la Santa Creu i Sant Pau\|University Hospital of Torrejon\|Fundación de investigación HM\|Hospital Sant Joan de Deu\|Hospital del Mar\|Hospital Universitario Infanta Leonor\|Hospital Universitario Fundación Alcorcón\|Hospital General de Segovia\|Institut Català de la Salut	Pregnancy Related\|COVID\|Covid-19	May 13, 2020	Phase 3
NCT04359316	Shahid Beheshti University of Medical Sciences	COVID-19	April 20, 2020	Phase 4
NCT04359615	Shahid Beheshti University of Medical Sciences	COVID-19	April 20, 2020	Phase 4
NCT04918524	Qilu Hospital of Shandong University	Connective Tissue Diseases\|Pregnancy Related	September 11, 2018
NCT05119140	Icahn School of Medicine at Mount Sinai\|Crohn´s and Colitis Foundation	Ulcerative Colitis (Disorder)	June 10, 2022	Phase 1\|Phase 2
NCT04328961	University of Washington\|Bill and Melinda Gates Foundation	COVID-19\|Corona Virus Infection\|SARS (Severe Acute Respiratory Syndrome)\|SARS-CoV-2	March 31, 2020	Phase 2\|Phase 3
NCT01379573	NYU Langone Health	Congenital Heart Block\|Neonatal Lupus\|Autoantibody-Associated Heart Block	January 1, 2011	Phase 2
NCT04333654	Sanofi	Coronavirus Infection	April 12, 2020	Phase 1
NCT01946880	National Institute of Allergy and Infectious Diseases (NIAID)\|Autoimmunity Centers of Excellence\|Rho Federal Systems Division, Inc.	Systemic Lupus Erythematosus\|SLE	November 20, 2013	Phase 2
NCT04365231	Hospital St. Joseph, Marseille, France	COVID19	April 1, 2020	Phase 3
NCT04334512	ProgenaBiome\|DSCS CRO	COVID-19\|Corona Virus Infection\|Coronavirus-19\|Sars-CoV2	June 22, 2020	Phase 2
NCT04351191	Government of Punjab, Specialized Healthcare and Medical Education Department\|Mayo Hospital Lahore\|Services Hospital, Lahore\|Pakistan Kidney and Liver Institute	Sars-CoV2\|Symptomatic Condition\|Covid-19	April 15, 2020	Phase 4
NCT04354870	NYU Langone Health	COVID-19	April 3, 2020	Phase 2
NCT02379650	University of Utah\|Intermountain Health Care, Inc.	Recurrent Pregnancy Loss\|Miscarriage	July 2016	Phase 2
NCT01602588	University College, London\|Cancer Research UK	Glioblastoma	May 2013	Phase 2
NCT02374021	Brigham and Women´s Hospital\|Columbia University	Arthritis, Rheumatoid	July 2016	Phase 4
NCT04712279	Corpometria Institute	Covid19	January 25, 2021	Phase 2\|Phase 3
NCT05126147	National Taiwan University Hospital	Graves Ophthalmopathy	December 1, 2021	Phase 4
NCT04691505	Brigham and Women´s Hospital\|National Institute on Aging (NIA)\|Rutgers University\|Johns Hopkins University	Rheumatoid Arthritis	December 23, 2020
NCT04466280	Baqiyatallah Medical Sciences University	COVID-19	August 12, 2020	Not Applicable
NCT04344444	LCMC Health	COVID-19	April 13, 2020	Phase 3
NCT04353336	Tanta University	COVID-19\|Coronavirus Infection	March 23, 2020	Phase 2\|Phase 3
NCT03825289	University of Utah\|Novartis Pharmaceuticals	Metastatic Pancreatic Carcinoma\|Stage II Pancreatic Cancer\|Stage IIA Pancreatic Cancer\|Stage IIB Pancreatic Cancer\|Stage III Pancreatic Cancer\|Stage IV Pancreatic Cancer\|Unresectable Pancreatic Carcinoma	January 18, 2019	Phase 1
NCT04964583	Coordinación de Investigación en Salud, Mexico\|Ultra Laboratorios SA. de CV.	Covid19	January 20, 2021	Phase 2\|Phase 3
NCT04363450	Louisiana State University Health Sciences Center in New Orleans\|Lafayette General Health\|University of Louisiana at Lafayette	COVID-19\|Corona Virus Infection\|Wuhan Coronavirus\|Prophylaxis\|Healthcare Worker\|Sars-CoV2\|Hydroxychloroquine	April 27, 2020	Phase 3
NCT04438837	Rambam Health Care Campus	Coronavirus Disease 2019 (COVID-19)\|Post-Exposure Prophylaxis	July 2020	Not Applicable
NCT04330144	Gangnam Severance Hospital	Contact Person From COVID-19 Confirmed Patient	April 1, 2020	Phase 3
NCT04464759	Ravi Amaravadi, MD\|Bristol-Myers Squibb\|Abramson Cancer Center of the University of Pennsylvania	Melanoma	October 21, 2020	Phase 1\|Phase 2
NCT04338698	Shehnoor Azhar\|University of Health Sciences Lahore	COVID 19	April 22, 2020	Phase 3
NCT04400019	University of Malaga\|Instituto de Investigacion Biomedica de Malaga\|Carlos III Health Institute	Sars-CoV2\|Coronavirus Infection\|Prevention & Control\|Nursing Home\|Hydroxychloroquine	September 2020	Phase 2\|Phase 3
NCT04343768	Shahid Beheshti University of Medical Sciences	COVID-19	April 9, 2020	Phase 2
NCT01689987	OHSU Knight Cancer Institute\|National Cancer Institute (NCI)	Recurrent Plasma Cell Myeloma\|Refractory Plasma Cell Myeloma	September 2012	Phase 1
NCT01232660	St Stephens Aids Trust	HIV Infection	October 2010	Phase 1
NCT00813423	National Cancer Institute (NCI)	Adult Solid Neoplasm	January 27, 2010	Phase 1
NCT04392973	King Abdullah International Medical Research Center	COVID19	May 21, 2020	Not Applicable
NCT04340349	Instituto Nacional de Rehabilitacion	Hydroxychloroquine\|Antimalarials\|Enzyme Inhibitors\|Antirheumatic Agents	February 1, 2021	Early Phase 1
NCT00311883	Vanderbilt University	Cystic Fibrosis	March 2006	Phase 1
NCT01941095	Hoffmann-La Roche	Rheumatoid Arthritis	November 20, 2013	Phase 3
NCT04022421	Assiut University	Behcet´s Syndrome, Vascular Type	October 1, 2018	Not Applicable
NCT05051137	Karolinska Institutet\|Harvard Medical School (HMS and HSDM)	Rheumatoid Arthritis	January 12, 2006
NCT00714181	Abramson Cancer Center of the University of Pennsylvania\|National Cancer Institute (NCI)	Unspecified Adult Solid Tumor, Protocol Specific	June 2008	Phase 1
NCT03085940	Indonesia University	Rheumatoid Arthritis	January 20, 2017	Not Applicable
NCT01266057	M.D. Anderson Cancer Center	Advanced Cancers	April 28, 2011	Phase 1
NCT01510119	Abramson Cancer Center of the University of Pennsylvania\|University of Pittsburgh\|Rutgers Cancer Institute of New Jersey	Metastatic Clear Cell Renal Cell Carcinoma	September 2011	Phase 1\|Phase 2
NCT04527549	ECOG-ACRIN Cancer Research Group\|National Cancer Institute (NCI)\|Eastern Cooperative Oncology Group	Clinical Stage IV Cutaneous Melanoma AJCC v8\|Locally Advanced Melanoma\|Pathologic Stage IIIC Cutaneous Melanoma AJCC v8\|Pathologic Stage IV Cutaneous Melanoma AJCC v8\|Unresectable Melanoma	October 23, 2020	Phase 2
NCT03081702	University Health Network, Toronto	Platinum-resistant Epithelial Ovarian Cancer	July 25, 2017	Phase 1\|Phase 2
NCT01128296	Amer Zureikat\|National Institutes of Health (NIH)\|University of Pittsburgh	Pancreatic Cancer	October 2010	Phase 1\|Phase 2
NCT04624269	Shanghai First Maternity and Infant Hospital\|Xinhua Hospital, Shanghai Jiao Tong University School of Medicine\|Shanghai Jiao Tong University Affiliated Sixth People´s Hospital\|Fudan University\|Zhejiang Provincial People´s Hospital\|Zhejiang Provincial Tongde Hospital	Antiphospholipid Syndrome\|Recurrent Miscarriage	December 1, 2020	Phase 4
NCT04132505	M.D. Anderson Cancer Center\|National Cancer Institute (NCI)	Metastatic Pancreatic Adenocarcinoma\|Stage IV Pancreatic Cancer AJCC v8	October 22, 2019	Phase 1
NCT04787991	Parker Institute for Cancer Immunotherapy\|Bristol-Myers Squibb\|Cancer Research Institute, New York City\|PsiOxus Therapeutics Ltd	Metastatic Pancreatic Adenocarcinoma	August 9, 2021	Phase 1
NCT02126683	National Taiwan University Hospital	Hashimoto´s Thyroiditis	April 2014	Not Applicable
NCT04335084	ProgenaBiome\|DSCS CRO	COVID-19\|Coronavirus Infection\|Sars-CoV2\|Corona Virus Infection\|COVID\|Coronavirus\|Coronavirus-19\|Coronavirus 19	June 22, 2020	Phase 2
NCT04329611	Dr. Michael Hill\|Alberta Health services\|University of Alberta\|University of Calgary\|Calgary Health Trust\|Alberta Innovates Health Solutions\|Government of Alberta	COVID-19	April 13, 2020	Phase 3
NCT01506973	Abramson Cancer Center of the University of Pennsylvania	Advanced Adenocarcinoma\|Metastatic Adenocarcinoma	December 2011	Phase 1\|Phase 2
NCT04394442	Samah Lutfy\|Zagazig University	COVID-19	March 21, 2020	Phase 2
NCT04363866	Oregon Health and Science University\|OHSU Knight Cancer Institute	COVID-19\|SARS-CoV-2	August 2020	Phase 2
NCT04328272	Prof. Dr. Umar Farooq\|Ayub Medical College, Abbottabad	COVID19	March 28, 2020	Phase 3
NCT04379492	Memorial Sloan Kettering Cancer Center	COVID-19\|COVID19\|Sars-CoV2\|SARS-Cov-2	May 5, 2020	Phase 2
NCT04669197	HonorHealth Research Institute	Untreated Resectable Pancreatic Adenocarcinoma\|Borderline Resectable Pancreatic Adenocarcinoma\|Locally Advanced Pancreatic Adenocarcinoma	December 1, 2020	Phase 2
NCT04342156	Tan Tock Seng Hospital\|National Center for Infectious Diseases\|Singapore Clinical Research Institute\|Singapore Eye Research Institute\|Saw Swee Hock School of Public Health\|Duke-NUS Graduate Medical School\|Netherlands: Ministry of Health, Welfare and Sports	Coronavirus Infection\|Hydroxychloroquine Adverse Reaction	April 2020	Phase 3
NCT04524702	Emory University\|National Cancer Institute (NCI)	Advanced Pancreatic Adenocarcinoma\|Metastatic Pancreatic Adenocarcinoma\|Stage IV Pancreatic Cancer AJCC v8	September 14, 2020	Phase 2
NCT04011410	Andrew C. James, MD\|University of Kentucky	Prostate Cancer Recurrent	December 3, 2019	Phase 2
NCT05084872	University Hospital, Toulouse	Mastocytosis	October 2021	Phase 2\|Phase 3
NCT04374942	Megan Landes\|University Health Network, Toronto	Pre-Exposure Prophylaxis\|Coronavirus\|SARS-CoV 2	April 30, 2020	Phase 3
NCT04376814	Baqiyatallah Medical Sciences University	COVID-19\|Favipiravir\|Kaletra\|Hydroxychloroquine\|Lopinavir+Ritonavir	March 29, 2020	Not Applicable
NCT03636152	VA Office of Research and Development	Chronic Kidney Disease\|Cardiovascular Disease\|Inflammation\|Atherosclerosis\|Aortic Stiffness	December 14, 2018	Phase 2
NCT03344172	Nathan Bahary, MD\|Pfizer\|National Cancer Institute (NCI)\|University of Pittsburgh	Pancreatic Cancer Resectable	December 13, 2017	Phase 2
NCT04349228	Abderrahmane Mami Hospital\|Eshmoun Clinical Research Center\|Datametrix	COVID19\|Sars-CoV2\|Hydroxychloroquine\|Prophylaxis\|Healthcare Worker	April 28, 2020	Phase 3
NCT04466540	Hospital Alemão Oswaldo Cruz\|EMS S+A\|Hospital do Coracao\|Hospital Israelita Albert Einstein\|Hospital Sirio-Libanes\|Hospital Moinhos de Vento\|Brazilian Research In Intensive Care Network	COVID-19	May 12, 2020	Phase 4
NCT03592823	First Affiliated Hospital of Harbin Medical University	Atrial Fibrillation	August 1, 2018	Phase 4
NCT03979651	Hospices Civils de Lyon	Metastatic NRAS Melanoma	October 15, 2019	Not Applicable
NCT02722369	University College, London	Small Cell Lung Cancer	March 14, 2017	Phase 2
NCT02451748	University of Illinois at Chicago\|UCB Pharma	Rheumatoid Arthritis	August 2015	Phase 4
NCT05518110	Cancer Trials Ireland\|Novartis	Pancreatic Cancer	September 15, 2022	Phase 2
NCT02303405	Charles Drew University of Medicine and Science	Diabetes Mellitus Type 2 With Hyperglycemia	November 2014	Phase 2
NCT00568880	Abramson Cancer Center of the University of Pennsylvania	Multiple Myeloma and Plasma Cell Neoplasm	September 8, 2010	Phase 1
NCT04332991	Massachusetts General Hospital\|National Heart, Lung, and Blood Institute (NHLBI)	Coronavirus\|Acute Respiratory Infection\|SARS-CoV Infection	April 2, 2020	Phase 3
NCT04954040	Maimónides Biomedical Research Institute of Córdoba	Acute Respiratory Distress Syndrome\|Covid19	February 10, 2021	Phase 2
NCT04435808	University of New Mexico	COVID-19	April 14, 2020	Phase 1\|Phase 2
NCT04374552	Rutgers, The State University of New Jersey	SARS-CoV-2 Infection	May 5, 2020	Phase 2
NCT04434144	Upazila Health & Family Planning Officer´s (UHFPO) Office, Chakoria, Cox´s Bazar	Ivermectin\|Hydroxychloroquine\|COVID19	May 2, 2020
NCT03791827	Xiqiang Dang\|The Children´s Hospital Affiliated to Suzhou University\|Shandong Provincial Hospital\|Guizhou Provincial People´s Hospital\|LanZhou University\|The First Affiliated Hospital of Inner Mongolia Medical College\|People´s Hospital of Zhangjiajie\|Puyang Oilfield General Hospital\|The First Affiliated Hospital of Anhui Medical University\|Guizhou Maternal and Child Health Care Hospital\|The Second Affiliated Hospital & Yuying Children´s Hospital of Wenzhou Medical University\|Shenzhen Children´s Hospital\|The Second Affiliated Hospital of Harbin Medical University\|Yichang Central People´s Hospital\|Xian Children´s Hospital\|Wuhan Children´s Hospital, Tongji Medical College, Huazhong University of Science & Technology\|The First People´s Hospital of Yunnan\|The First Affiliated Hospital of Xiamen University\|The First Affiliated Hospital of Xinxiang Medical College\|Shanxi Provincial Maternity and Children´s Hospital\|Liaocheng People´s Hospital\|Fujian Provincial Hospital\|First Affiliated Hospital of Guangxi Medical University\|Second Hospital of Lanzhou University\|Guangzhou First People´s Hospital\|The Second Hospital of Shandong University\|Children´s Hospital of Hebei Province\|Beijing Children´s Hospital\|Zhengzhou Children´s Hospital\|The Children´s Hospital of Chongqing Medical University\|Wuxi Children´s Hospital\|The Children´s Hospital of Fudan University\|Shanghai Children´s Medical Center\|Qilu Children´s Hospital of Shandong University\|Second Xiangya Hospital of Central South University	Lupus Nephritis\|Children\|Steroid\|Immunosuppressive Treatment	December 1, 2018
NCT04322396	Chronic Obstructive Pulmonary Disease Trial Network, Denmark	Virus Diseases\|Infection Viral\|Corona Virus Infection	April 6, 2020	Phase 2
NCT05110651	Nicholas Carlson\|Rigshospitalet, Denmark	COVID-19\|End Stage Renal Disease	April 10, 2020	Phase 4
NCT04497519	University Medical Center Groningen	Covid19	September 15, 2020	Phase 1
NCT01272310	Sheba Medical Center	Chronic Hepatitis C	January 2011	Phase 1\|Phase 2
NCT04261517	Shanghai Public Health Clinical Center	Pneumonia, Pneumocystis\|Coronavirus\|COVID-19	February 6, 2020	Phase 3
NCT05237843	Ain Shams University	Recurrent Pregnancy Loss	March 1, 2022	Phase 1
NCT01480154	National Cancer Institute (NCI)	Advanced Malignant Solid Neoplasm\|Stage III Cutaneous Melanoma AJCC v7\|Stage III Prostate Cancer AJCC v7\|Stage III Renal Cell Cancer AJCC v7\|Stage IIIA Cutaneous Melanoma AJCC v7\|Stage IIIB Cutaneous Melanoma AJCC v7\|Stage IIIC Cutaneous Melanoma AJCC v7\|Stage IV Cutaneous Melanoma AJCC v6 and v7\|Stage IV Prostate Cancer AJCC v7\|Stage IV Renal Cell Cancer AJCC v7	November 23, 2011	Phase 1
NCT05026801	Iterum Therapeutics, International Limited\|Waterbury Hospital	Respiratory Tract Infection Viral	February 8, 2021	Phase 3
NCT04341870	Assistance Publique - Hôpitaux de Paris	COVID19\|SARS-CoV-2 Infection	April 11, 2020	Phase 2\|Phase 3
NCT04332094	Fundació Institut de Recerca de l´Hospital de la Santa Creu i Sant Pau\|Instituto de Salud Carlos III	COVID-19	April 2, 2020	Phase 2
NCT04347980	Centre Chirurgical Marie Lannelongue	Respiratory Distress Syndrome, Adult\|COVID-19	April 17, 2020	Phase 3
NCT04373044	University of Southern California\|National Cancer Institute (NCI)	Symptomatic COVID-19 Infection Laboratory-Confirmed	May 1, 2020	Phase 2
NCT04201457	Pediatric Brain Tumor Consortium	Low Grade Glioma (LGG) of Brain With BRAF Aberration\|High Grade Glioma (HGG) of the Brain With BRAF Aberration\|Low Grade Glioma of Brain With Neurofibromatosis Type 1	November 20, 2019	Phase 1\|Phase 2
NCT04321616	Oslo University Hospital	SARS-CoV Infection\|COVID 19\|Acute Respiratory Distress Syndrome ARDS	March 28, 2020	Phase 2\|Phase 3
NCT02444728	Chinese SLE Treatment And Research Group\|Peking Union Medical College Hospital	Thrombocytopenia	July 2015	Phase 3
NCT01537315	University of Arkansas	Kidney Failure, Chronic\|Cardiovascular Disease\|Arteriosclerosis	February 2012	Phase 2
NCT03671174	RenJi Hospital\|The First Affiliated Hospital of Anhui Medical University\|China-Japan Union Hospital, Jilin University\|Wuxi No. 2 People´s Hospital\|The First Affiliated Hospital with Nanjing Medical University\|Xiangya Hospital of Central South University	Undifferentiated Connective Tissue Disease\|Recurrent Pregnancy Loss	August 2, 2019	Not Applicable
NCT04347512	University Hospital, Strasbourg, France	Sars-CoV-2, Community-Acquired Pneumonia,COVID-19	June 2, 2020	Phase 3
NCT04460547	Qassim University	COVID-19	July 25, 2020
NCT04329832	Intermountain Health Care, Inc.\|University of Utah	COVID-19	March 30, 2020	Phase 2
NCT04383717	Cairo University	Respiratory Tract Infections	May 5, 2020	Phase 3
NCT03025087	Duke University	Individuals Undergoing Cardiac and General Surgery	June 19, 2017	Phase 4
NCT04336332	Rutgers, The State University of New Jersey	SARS-CoV-2\|COVID-19	April 1, 2020	Phase 2
NCT04334967	Providence Health & Services\|Center for Outcomes Research and Education\|Providence Cancer Center, Earle A. Chiles Research Institute	COVID-19\|Corona Virus Infection\|SARS-CoV-2\|2019-nCoV\|2019 Novel Coronavirus	March 30, 2020	Phase 4
NCT04382625	Kootenai Health\|Washington State University	SARS-CoV-2 Pneumonia\|COVID-19	October 2020	Phase 4
NCT04354428	University of Washington\|Bill and Melinda Gates Foundation	COVID-19\|SARS-CoV-2	April 16, 2020	Phase 2\|Phase 3
NCT04341207	Gustave Roussy, Cancer Campus, Grand Paris	Cancer & COVID 19	April 3, 2020	Phase 2
NCT04333225	Baylor Research Institute	COVID-19	April 3, 2020	Phase 2
NCT04316377	University Hospital, Akershus	Corona Virus Infection	March 25, 2020	Phase 4
NCT03414502	University of Nebraska	Rheumatoid Arthritis	August 2007	Phase 3
NCT01573754	The University of Texas Medical Branch, Galveston	Porphyria Cutanea Tarda	March 21, 2006	Phase 2
NCT04858633	Postgraduate Institute of Medical Education and Research	Covid19\|COVID-19 Prevention	March 22, 2021	Phase 3
NCT04351724	Medical University of Vienna\|Kaiser Franz Josef Hospital\|SMZ-Ost Donauspital\|Otto Wagner Hospital\|Hospital Hietzing\|Wilhelminenspital Vienna\|Medical University Innsbruck\|Medical University of Graz\|Kepler University Hospital	COVID-19	April 16, 2020	Phase 2\|Phase 3
NCT04344379	Assistance Publique - Hôpitaux de Paris	SARS-CoV-2 Infection	April 17, 2020	Phase 3
NCT03400254	Abramson Cancer Center of the University of Pennsylvania\|Translational Breast Cancer Research Consortium\|Pfizer\|Hoosier Cancer Research Network\|Breast Cancer Research Foundation	Breast Cancer	February 26, 2019	Phase 1\|Phase 2
NCT04377646	Military Hospital of Tunis\|UR17DN02 : Autoimmune Diseases Research Unit\|Dacima Consulting	Sars-CoV2\|COVID19	May 4, 2020	Phase 3
NCT01006369	Rutgers, The State University of New Jersey\|National Cancer Institute (NCI)	Colorectal Cancer	May 2009	Phase 2
NCT03540810	University Hospital, Angers	Primary Antiphospholipid Syndrome	August 15, 2018	Phase 3
NCT04981145	Second Affiliated Hospital, School of Medicine, Zhejiang University	Primary Sjögren´s Syndrome	January 14, 2022	Phase 4
NCT04735068	Abramson Cancer Center of the University of Pennsylvania\|Pfizer	Non-Small Cell Lung Cancer\|KRAS Mutation-Related Tumors	April 9, 2021	Phase 2
NCT04346667	Government of Punjab, Specialized Healthcare and Medical Education Department\|Mayo Hospital Lahore\|Services Institute of Medical Sciences, Pakistan\|Pakistan Kidney and Liver Institute\|Forman Christian College, Pakistan\|Harvard School of Public Health (HSPH)	SARS-CoV-2\|Coronavirus Infection\|Asymptomatic Condition\|COVID-19	April 14, 2020	Phase 4
NCT04214418	Columbia University\|Genentech, Inc.	Gastrointestinal Cancer	February 12, 2020	Phase 1\|Phase 2
NCT04355026	General and Teaching Hospital Celje	Covid-19	April 10, 2020	Phase 4
NCT04532346	Children´s Hospital of Fudan University	Interstitial Lung Disease\|Surfactant Dysfunction	August 2022	Early Phase 1
NCT04429867	WellStar Health System	COVID-19	May 7, 2020	Phase 4
NCT04522466	Centre Hospitalier Universitaire de Saint Etienne\|CHU Saint-Etienne - Laboratoire de Pharmacologie - Toxicologie - Gaz du sang	Sars-CoV2	April 3, 2020	Phase 3
NCT04443725	Cairo University	COVID-19	July 2020	Phase 2\|Phase 3
NCT04421664	McGill University Health Centre+Research Institute of the McGill University Health Centre\|University of Manitoba\|University of Alberta\|University of British Columbia\|McMaster University\|Lawson Health Research Institute\|Eastern Health\|University of Minnesota	Corona Virus Infection\|SARS-CoV Infection\|Coronavirus	March 25, 2020	Phase 3
NCT02756546	Cairo University	Systemic Lupus Erythematosis	September 2014	Phase 1\|Phase 2
NCT03377179	RedHill Biopharma Limited	Cholangiocarcinoma\|Cholangiocarcinoma Non-resectable\|Cholangiocarcinoma, Perihilar\|Cholangiocarcinoma, Extrahepatic\|Cholangiocarcinoma, Intrahepatic	March 7, 2018	Phase 2
NCT04352946	GeoSentinel Foundation	Prophylaxis\|COVID-19\|Health Care Worker\|Hydroxychloroquine	April 24, 2020	Phase 3
NCT04873895	Abramson Cancer Center of the University of Pennsylvania\|Pfizer	Colorectal Neoplasms Malignant	January 24, 2022	Phase 1
NCT04359953	University Hospital, Strasbourg, France	COVID-19 Infection	April 25, 2020	Phase 3
NCT03813771	University of Leeds\|Samsung Bioepis Co., Ltd.	Rheumatoid Arthritis	March 2019	Phase 4
NCT04394182	Fundacion GenesisCare\|Hospital La Milagrosa\|Hospital Vithas Valencia Consuelo	Pneumonia, Viral\|Cytokine Storm	April 21, 2020	Not Applicable
NCT00946790	Sandoz	Immunosuppression\|Rheumatism	July 1993	Phase 1
NCT04351620	University of Chicago	COVID-19	April 2020	Phase 1
NCT02433184	University of Leeds	Rheumatoid Arthritis	July 2011	Phase 4
NCT02735707	UMC Utrecht\|Australian and New Zealand Intensive Care Research Centre\|Medical Research Institute of New Zealand\|Unity Health\|Berry Consultants\|Global Coalition for Adaptive Research\|University of Pittsburgh Medical Center\|Intensive Care National Audit & Research Centre\|St. Marianna University School of Medicine\|National Intensive Care Surveillance MORU	Community-acquired Pneumonia, Influenza, COVID-19	April 11, 2016	Phase 3
NCT04860284	Makerere University	Covid19	September 18, 2020	Phase 2
NCT01417403	Virginia Commonwealth University\|National Cancer Institute (NCI)	Bone Metastases\|Unspecified Adult Solid Tumor, Protocol Specific	August 2011	Phase 1
NCT04414241	Universidad Peruana Cayetano Heredia	SARS-CoV-2	June 25, 2020	Phase 3
NCT04368351	University of Roma La Sapienza	COVID\|Pneumonia\|Diarrhea	March 1, 2020
NCT00771056	Northwell Health	B-Cell Chronic Lymphocytic Leukemia	July 2008	Phase 2
NCT00259610	University of Alabama at Birmingham\|Amgen\|Barr Laboratories\|Pfizer	Rheumatoid Arthritis	May 2004	Phase 4
NCT03754179	Universitair Ziekenhuis Brussel\|University Hospital, Ghent	Melanoma	January 23, 2018	Phase 1\|Phase 2
NCT04385264	Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland	COVID-19	January 2022	Phase 2\|Phase 3
NCT04362332	UMC Utrecht\|ZonMw: The Netherlands Organisation for Health Research and Development	COVID-19	April 14, 2020	Phase 4
NCT04353271	University of South Alabama	Covid 19\|Corona Virus Infection	April 17, 2020	Phase 2\|Phase 3
NCT02124681	University of Pittsburgh	Insulin Resistance	April 2014	Phase 1
NCT02200146	University of Milano Bicocca\|Agenzia Italiana del Farmaco	Pulmonary Sarcoidosis	March 2009	Phase 3
NCT04346329	Universidad Nacional de Colombia\|Fundación Salud de los Andes	COVID	March 30, 2020	Phase 3
NCT04590274	International Brain Research Foundation	Covid19\|SARS (Severe Acute Respiratory Syndrome)	November 2020	Phase 1
NCT04395768	National Institute of Integrative Medicine, Australia	COVID19	September 9, 2020	Phase 2
NCT04446104	National University Hospital, Singapore	Covid-19	May 13, 2020	Phase 3
NCT04354441	Sir Mortimer B. Davis - Jewish General Hospital	COVID-19\|SARS-CoV-2\|Pregnant Women\|Hydroxychloroquine	May 2020	Phase 2
NCT04077957	Nanfang Hospital of Southern Medical University	Ankylosing Spondylitis\|Spondyloarthritis	October 7, 2019	Phase 4
NCT00909831	Abramson Cancer Center of the University of Pennsylvania\|National Cancer Institute (NCI)	Unspecified Adult Solid Tumor, Protocol Specific	October 2008	Phase 1
NCT02615938	Matthias Griese\|Ludwig-Maximilians - University of Munich	Interstitial Lung Disease\|Diffuse Parenchymal Lung Disease\|Children´s Interstitial Lung Disease	April 2015	Phase 2
NCT04336748	Medical University of Vienna	Sars-CoV2\|Infection Viral\|Healthcare Worker\|Prophylaxis	April 2020	Phase 3
NCT04153201	National and Kapodistrian University of Athens	Antiphospholipid Syndrome	January 15, 2013	Not Applicable
NCT04981379	Health Institutes of Turkey	Covid19	November 16, 2020	Phase 3
NCT04386057	Kimberly Perez\|Eli Lilly and Company\|Dana-Farber Cancer Institute	Pancreatic Cancer\|Advanced Cancer	May 27, 2020	Phase 2
NCT04328467	University of Minnesota	COVID-19\|Corona Virus Infection\|ARDS\|Acute Respiratory Distress Syndrome	April 6, 2020	Phase 3
NCT04391127	Centenario Hospital Miguel Hidalgo	COVID-19	May 4, 2020	Phase 3
NCT04755322	Assiut University	Hydroxychloroquine	March 1, 2021	Not Applicable
NCT04363827	Istituto Scientifico Romagnolo per lo Studio e la cura dei Tumori\|University of Bologna	COVID19\|Hydroxychloroquine\|Prophylaxis\|Treatment\|SARS-CoV-2	May 14, 2020	Phase 2
NCT04345653	Hackensack Meridian Health	Covid19	April 14, 2020	Phase 2
NCT00728845	University of Medicine and Dentistry of New Jersey\|National Cancer Institute (NCI)\|Rutgers, The State University of New Jersey	Lung Cancer	June 16, 2008	Phase 1\|Phase 2
NCT02316340	The University of Texas Health Science Center at San Antonio	Colorectal Cancer	February 11, 2015	Phase 2
NCT00632866	Assistance Publique - Hôpitaux de Paris\|Sanofi	Primary Sjögren´s Syndrome	March 2008	Phase 3
NCT00962845	Rutgers, The State University of New Jersey\|National Cancer Institute (NCI)\|Rutgers Cancer Institute of New Jersey	Melanoma (Skin)	September 2010	Early Phase 1
NCT01833845	BioLineRx, Ltd.	Hepatitis C	April 2013	Phase 1\|Phase 2
NCT01273805	Dana-Farber Cancer Institute\|Brigham and Women´s Hospital\|Massachusetts General Hospital	Pancreatic Cancer	January 2011	Phase 2
NCT01207739	Radboud University Medical Center\|Sint Maartenskliniek\|ZonMw: The Netherlands Organisation for Health Research and Development	Lyme Disease\|Borrelia Infection	September 2010	Phase 4
NCT03856866	The Hospital for Sick Children	Zellweger Syndrome\|Peroxisome Biogenesis Disorders	January 11, 2019	Phase 2
NCT04318015	National Institute of Respiratory Diseases, Mexico	COVID-19\|Severe Acute Respiratory Syndrome	April 14, 2020	Phase 3
NCT04316494	Guy´s and St Thomas´ NHS Foundation Trust\|Medical Research Council	ANCA Associated Vasculitis\|Microscopic Polyangiitis\|Churg-Strauss Syndrome\|Wegener Granulomatosis	December 17, 2020	Phase 4
NCT00413361	Assistance Publique - Hôpitaux de Paris\|Sanofi-Synthelabo	Systemic Lupus Erythematosus	June 2007	Phase 4
NCT05626348	Qilu Hospital of Shandong University	Arthritis, Rheumatoid	December 22, 2021	Phase 4
NCT04566133	National Cancer Institute (NCI)\|National Institutes of Health Clinical Center (CC)	Bile Duct Cancer\|Biliary Cancer\|Biliary Tract Neoplasms\|Cholangiocarcinoma	February 15, 2022	Phase 2
NCT04318444	Columbia University	COVID-19\|Corona Virus Infection	March 29, 2020	Phase 2\|Phase 3
NCT02714634	University Hospital, Strasbourg, France	Rheumatoid Arthritis\|Insufficient Response to Methotrexate or Leflunomide	March 30, 2016	Phase 4
NCT04361318	Tanta University	COVID-19	May 2020	Phase 2\|Phase 3
NCT01206530	Abramson Cancer Center of the University of Pennsylvania	Rectal Cancer\|Colon Cancer\|Metastasis\|Adenocarcinoma	September 2010	Phase 1\|Phase 2
NCT04458948	University of New Mexico	COVID-19	March 24, 2020	Phase 2
NCT03019926	University Hospital Center of Martinique	Systemic Lupus, Skin Lupus	January 19, 2017
NCT01227135	Lynn McMahon\|Medical Research Council\|CRUK Trials unit Glasgow\|University of Glasgow	Leukemia	March 2010	Phase 2
NCT04341441	Henry Ford Health System	COVID-19\|Coronavirus\|Coronavirus Infections\|SARS-CoV 2	April 7, 2020	Phase 3
NCT03215264	Abramson Cancer Center of the University of Pennsylvania	Colorectal Cancer	October 2, 2017	Phase 1\|Phase 2
NCT04437693	Hamad Medical Corporation	COVID 19	August 31, 2020	Phase 2\|Phase 3
NCT01897116	Abramson Cancer Center of the University of Pennsylvania	Melanoma	June 2013	Phase 1
NCT02930343	Jawaharlal Institute of Postgraduate Medical Education & Research	Rheumatoid Arthritis	September 2016	Phase 3
NCT04322123	Hospital do Coracao\|Hospital Israelita Albert Einstein\|Hospital Sirio-Libanes\|Brazilian Research In Intensive Care Network\|EMS	Coronavirus Infections	April 1, 2020	Phase 3
NCT04303507	University of Oxford	COVID19\|Coronavirus\|Acute Respiratory Illnesses	April 29, 2020	Not Applicable
NCT00031824	Children´s Oncology Group\|National Cancer Institute (NCI)	Graft Versus Host Disease	April 2002	Phase 3
NCT04403100	Cardresearch\|Cardresearch - Cardiologia Assistencial e de Pesquisa LTDA\|Cytel Inc.	COVID-19\|Coronavirus Infection\|Virus Disease\|Acute Respiratory Infection\|SARS-CoV Infection	June 3, 2020	Phase 3
NCT04349592	Hamad Medical Corporation	Covid19	April 14, 2020	Not Applicable
NCT04369742	NYU Langone Health\|State University of New York - Downstate Medical Center	COVID-19	April 15, 2020	Phase 2
NCT04370015	Services Institute of Medical Sciences, Pakistan	SARS-CoV-2\|Healthcare Workers	May 15, 2020	Not Applicable
NCT04575558	Latin American Cooperative Oncology Group\|Oncoclínicas	Sars-CoV2	June 30, 2020	Phase 2
NCT01396200	Abramson Cancer Center of the University of Pennsylvania	Myeloma	June 2011	Early Phase 1
NCT01550367	Leonard Appleman\|Prometheus Laboratories\|University of Pittsburgh	Metastatic Renal Cell Carcinoma	March 2012	Phase 1\|Phase 2
NCT04359537	Shaheed Zulfiqar Ali Bhutto Medical University	COVID 19	May 1, 2020	Phase 2
NCT02603146	National Institute of Allergy and Infectious Diseases (NIAID)\|Autoimmunity Centers of Excellence	Healthy Participants\|Rheumatoid Arthritis (RA) Prevention	April 27, 2016	Phase 2
NCT02421575	Rutgers, The State University of New Jersey\|National Cancer Institute (NCI)\|Rutgers Cancer Institute of New Jersey	Prostate Carcinoma	July 2012	Early Phase 1
NCT04005768	Universitaire Ziekenhuizen KU Leuven	Obesity	August 1, 2019	Phase 4
NCT01026844	Massachusetts General Hospital\|Genentech, Inc.	Non-small Cell Lung Cancer	July 2007	Phase 1
NCT03037437	The University of Texas Health Science Center at San Antonio	Hepatocellular Cancer	February 16, 2017	Phase 2
NCT04161339	Instituto de Cardiologia do Rio Grande do Sul\|Hospital de Clinicas de Porto Alegre	Cardiovascular Diseases\|Endothelial Dysfunction\|Sleep Apnea\|Atherosclerosis\|Coronary Artery Disease	July 1, 2019	Phase 4
NCT04371926	Texas Cardiac Arrhythmia Research Foundation	COVID-19	June 2020	Not Applicable
NCT01495403	Mayo Clinic	Liver Cirrhosis\|Muscle Cramps	December 2011	Early Phase 1
NCT03428945	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)\|Juvenile Diabetes Research Foundation	Type1 Diabetes Mellitus	August 15, 2018	Phase 2
NCT04315948	Institut National de la Santé Et de la Recherche Médicale, France	Corona Virus Infection	March 22, 2020	Phase 3
NCT04340544	University Hospital Tuebingen\|Robert Bosch Medical Center\|Universitätsklinikum Hamburg-Eppendorf\|Bernhard Nocht Institute for Tropical Medicine	COVID-19	April 22, 2020	Phase 2
NCT04477083	Mansoura University	Covid19\|Hydroxychloroquine Adverse Reaction	July 15, 2020	Not Applicable
NCT05287321	Yoo-min Kim\|Ministry of Health & Welfare, Korea\|Chung-Ang University Hosptial, Chung-Ang University College of Medicine	Preeclampsia	April 15, 2022	Phase 3
NCT03015324	Peng Wang, MD PhD\|University of Kentucky	Solid Tumor	August 8, 2017	Phase 1
NCT04714515	University of Sargodha\|Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine\|Shaukat Khanum Memorial Cancer Hospital & Research Centre\|Shanghai Jiao Tong University School of Medicine\|Teesside University	Covid19\|SARS-CoV-2 Infection	February 20, 2020
NCT04335552	Duke University	SARS-CoV-2	April 17, 2020	Phase 2
NCT04308668	University of Minnesota\|McGill University Health Centre+Research Institute of the McGill University Health Centre\|University of Manitoba\|University of Alberta	Corona Virus Infection\|Acute Respiratory Distress Syndrome\|SARS-CoV Infection\|Coronavirus\|Coronavirus Infections	March 17, 2020	Phase 3
NCT04350671	Shahid Beheshti University of Medical Sciences	COVID-19	April 15, 2020	Phase 4
NCT03305263	Rigshospitalet, Denmark	Recurrent Pregnancy Loss	January 25, 2018	Phase 3
NCT04390061	Università Politecnica delle Marche\|Azienda Ospedaliera Ospedali Riuniti Marche Nord\|Ospedale Civile Santo Spirito, Pescara\|Università Magna Grecia, Catanzaro\|ASST Papa Giovanni XXIII, Bergamo\|Azienda Ospedaliero Universitaria Policlinico Umberto I, Roma\|ASST Cremona, Cremona\|Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milano\|Ospedale di Circolo e Fondazione Macchi, Varese	Pneumonitis, Interstitial\|COVID-19	June 2020	Phase 2
NCT04228263	Assiut University	Hydroxychloroquine	January 1, 2020	Not Applicable
NCT02913157	University of Calgary	Multiple Sclerosis, Primary Progressive	November 2016	Phase 2
NCT04746365	Elaraby Hospital\|Shebin El-Kom Teaching Hospital	Covid19	December 6, 2020	Phase 4
NCT01634893	The University of Texas Health Science Center at San Antonio	Refractory or Relapsed Solid Tumors	June 2012	Phase 1
NCT04371406	Assistance Publique - Hôpitaux de Paris	Covid-19	April 2020	Phase 3
NCT02595346	University Hospital, Rouen	Antiphospholipid Syndrome (APS)	June 2016	Phase 2
NCT01494155	Massachusetts General Hospital	Pancreatic Cancer	December 2011	Phase 2
NCT00977470	Massachusetts General Hospital\|Stanford University\|Yale University\|University of Maryland, College Park\|Genentech, Inc.	Non-small Cell Lung Cancer	October 2009	Phase 2
NCT02910076	Hadassah Medical Organization	Diabetes Type Two	October 2016	Phase 1\|Phase 2
NCT04354649	AHS Cancer Control Alberta	Arthritis\|Arthralgia	July 29, 2021	Phase 2
NCT04307693	Asan Medical Center	COVID-19	March 11, 2020	Phase 2
NCT00102557	National Institute of Dental and Craniofacial Research (NIDCR)\|National Institutes of Health Clinical Center (CC)	Lichen Planus, Oral	January 2005	Phase 2
NCT03513211	St Vincent´s Hospital, Sydney	Prostate Cancer	August 23, 2018	Phase 1\|Phase 2
NCT04347031	Burnasyan Federal Medical Biophysical Center	Pneumonia, Viral\|Respiratory Failure	April 8, 2020	Phase 2\|Phase 3
NCT04350281	The University of Hong Kong	COVID	April 9, 2020	Phase 2
NCT02631252	Alison Sehgal, MD, MS\|University of Pittsburgh	Leukemia, Acute Myelogenous	August 18, 2016	Phase 1
NCT04569890	RenJi Hospital	Rheumatoid Arthritis\|Pregnancy Related	December 1, 2020	Not Applicable
NCT04338906	Heinrich-Heine University, Duesseldorf\|Universitätsklinikum Hamburg-Eppendorf\|University Hospital Frankfurt\|St. Georg Hospital Leipzig, Germany\|Hospital Schwabing Munich, Germany\|Missioklinik, Wuerzburg, Germany	COVID	May 2020	Phase 4
NCT04387760	Royal College of Surgeons in Ireland - Medical University of Bahrain\|Ebrahim Khalil Kanoo Community Medical Center\|Hereditary blood Disorder Centre - Salmaniya Medical Complex\|Mohammed Bin Khalifa Bin Sulman Al Khalifa Cardiac Centre, Awali\|Jidhafs COVID-19 Centre\|Sitra FICU\|Salmaniya Medical Complex- 6th Floor\|Salmaniya Medical Complex- Helipad	SARS-CoV 2\|COVID-19	August 11, 2020	Phase 2
NCT03032406	Abramson Cancer Center of the University of Pennsylvania	Breast Cancer Stage IIB	January 23, 2017	Phase 2
NCT04321278	Hospital Israelita Albert Einstein\|EMS\|Hospital do Coracao\|Hospital Sirio-Libanes\|Brazilian Research In Intensive Care Network	Coronavirus Infections\|Pneumonia, Viral	March 28, 2020	Phase 3
NCT01842594	Shin Kong Wu Ho-Su Memorial Hospital	Sarcoma	August 2012	Phase 2
NCT03275870	Elena Gonzalez Brant, MD\|University of Pittsburgh	Hidradenitis Suppurativa\|Hidradenitis\|Acne Inversa\|Boils\|Follicular Occlusion Triad\|Follicular Occlusion Tetrad	September 28, 2017	Phase 1\|Phase 2
NCT04573153	ScandiBio Therapeutics AB\|Istanbul Medipol University Hospital\|Istanbul Umraniye Training and Research Hospital\|Bakirkoy Dr. Sadi Konuk Research and Training Hospital\|Dr. Lutfi Kirdar Kartal Training and Research Hospital\|Bagcilar Training and Research Hospital\|Kanuni Sultan Suleyman Training and Research Hospital\|Alanya Alaaddin Keykubat University Alanya Training and Research Hospital\|Canakkale 18 Mart University Health Research and Application Hospital\|Monitor CRO	COVID-19	September 21, 2020	Phase 2\|Phase 3
NCT04329923	Ravi Amaravadi, MD\|University of Pennsylvania	COVID-19	April 9, 2020	Phase 2
NCT04973566	Janssen Research & Development, LLC	Healthy	August 31, 2021	Phase 1
NCT00873496	Ege University	Sjögren´s Syndrome\|Xerostomia	January 2005
NCT04350684	Shahid Beheshti University of Medical Sciences	COVID-19	April 15, 2020	Phase 4
NCT04779047	October 6 University\|Beni-Suef University	Covid19\|Pneumonia	October 1, 2020	Phase 4
NCT04345861	University Hospital, Montpellier	Coronavirus Infection\|Pneumonia, Viral	April 11, 2020	Phase 2\|Phase 3

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

1M HCl : 100 mg/mL ( 297.73 mM ; adjust pH to 2 with HCl)

H ₂ O : 1.67 mg/mL ( 4.97 mM ; ultrasonic and warming and heat to 60°C)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9773 mL	14.8867 mL	29.7734 mL
5 mM	0.5955 mL	2.9773 mL	5.9547 mL
10 mM	0.2977 mL	1.4887 mL	2.9773 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6.
[2] Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40.
[3] Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Mar 9. pii: ciaa237.

Synonyms

Ethanol, 2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-

Ethanol, 2-[[4-[(7-chloro-4-quinolyl)amino]pentyl]ethylamino]-

2-[[4-[(7-Chloro-4-quinolinyl)amino]pentyl]ethylamino]ethanol

WIN 1258

7-Chloro-4-[4-(N-ethyl-N-β-hydroxyethylamino)-1-methylbutylamino]quinoline

7-Chloro-4-[4-[ethyl(2-hydroxyethyl)amino]-1-methylbutylamino]quinoline

7-Chloro-4-[5-(N-ethyl-N-2-hydroxyethylamino)-2-pentyl]aminoquinoline

Hydroxychloroquine

Oxychlorochin

Win 1258-2

Racemic Hydroxychloroquine

(±)-Hydroxychloroquine

Oxichloroquine

Oxychloroquine

2-([4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino)ethan-1-ol

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