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[CAS NO. 118081-34-8] Ceftibuten dihydrate
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-B0698A |
| Brand: | MCE |
| CAS: | 118081-34-8 |
Overview
| MDL | MFCD08141796 |
|---|---|
| Molecular Weight | 446.46 |
| Molecular Formula | C15H18N4O8S2 |
| SMILES | O=C(C(N12)=CCS[C@]2([H])[C@H](NC(/C(C3=CSC(N)=N3)=C\CC(O)=O)=O)C1=O)O.O.O |
1 Publications Citing Use of MCE
Summary
Ceftibuten (Sch-39720) dihydrate, an antibiotic , is an orally active cephalosporin, possesses potent activity in vitro against a wide range of gram-negative and certain gram-positive pathogens [1] [2] .
In Vitro
Ceftibuten (Sch-39720) is highly active against Haemophilus influenza , Escherichia coli , Klebsiella sp., and Proteus sp. and moderately active against Serratia sp. and Streptococcus pyogenes . Ceftibuten is relatively inactive against enterococci and staphylococci and is only weakly active against Pseudomonas aeruginosa and obligate anaerobes. It is also stable in the presence of most β-lactamase-producing organisms except β Bacteroides fragilis . Ceftibuten is very active against strains of the family Enterobacteriaceae (mean MIC for 90% of strains=0.25 μg/ml) but less active against Campylobacterjejuni (mean MIC for 90% of strains=16.0 μg/ml) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Ceftibuten, a biologically stableβ-lactam antibiotic, has been shown to be transported by the small peptide transport system, to have relatively high affinity for the carrier and to show clear stereoselective and proton-gradient dependent transport characteristics in rat intestinal brush-border membrane vesicles [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT00724256 | IRCCS Burlo Garofolo |
Pyelonephritis
|
July 2006 | Phase 3 |
| NCT05488678 | Venatorx Pharmaceuticals, Inc.|National Institute of Allergy and Infectious Diseases (NIAID) |
Pharmacokinetics
|
October 12, 2022 | Phase 1 |
| NCT04877379 | Venatorx Pharmaceuticals, Inc.|National Institute of Allergy and Infectious Diseases (NIAID) |
Healthy Subjects
|
June 8, 2021 | Phase 1 |
| NCT05527834 | Venatorx Pharmaceuticals, Inc.|National Institute of Allergy and Infectious Diseases (NIAID) |
Pharmacokinetics
|
September 13, 2022 | Phase 1 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 223.98 mM ; Need ultrasonic)
H 2 O : 100 mg/mL ( 223.98 mM ; ultrasonic and warming and heat to 80°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.2398 mL | 11.1992 mL | 22.3984 mL |
| 5 mM | 0.4480 mL | 2.2398 mL | 4.4797 mL |
| 10 mM | 0.2240 mL | 1.1199 mL | 2.2398 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution
-
3.
Add each solvent one by one: PBS
Solubility: 2.26 mg/mL (5.06 mM); Clear solution; Need ultrasonic
References
- [1] Kearns GL, et al. Single-dose pharmacokinetics of ceftibuten (SCH 39720) in infants and children. Antimicrob Agents Chemother. 1991;35(10):2078-2084.
- [2] Shawar R, et al. Comparative in vitro activity of ceftibuten (Sch 39720) against bacterial enteropathogens. Antimicrob Agents Chemother. 1989;33(5):781-784.
- [3] Tamai I, et al. Functional expression of intestinal dipeptide/beta-lactam antibiotic transporter in Xenopus laevis oocytes. Biochem Pharmacol. 1994;48(5):881-888.
Synonyms
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