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[CAS NO. 1191-85-1] Eicosatetraynoicacid
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-124108 |
| Brand: | MCE |
| CAS: | 1191-85-1 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 296.40 |
| Molecular Formula | C20H24O2 |
| SMILES | CCCCCC#CCC#CCC#CCC#CCCCC(O)=O |
Summary
Eicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipoxygenase ( ID 50 =8 μM and 4 μM, respectively) [1] . Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 µM [2] . Eicosatetraynoic acid specifically interferes with the replication of the cowpox virus both in vivo and in vitro [3] .
IC50 & Target
|
COX 8 μM (ID 50 ) |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|
* The compound is unstable in solutions, freshly prepared is recommended.
Solvent & Solubility
DMSO : 2 mg/mL ( 6.75 mM ; Need ultrasonic)
Ethanol : 1 mg/mL ( 3.37 mM ; Need ultrasonic and warming)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.3738 mL | 16.8691 mL | 33.7382 mL |
| 5 mM | 0.6748 mL | 3.3738 mL | 6.7476 mL |
| 10 mM | --- | --- | --- |
References
- [1] Hammarström S, et al. Selective inhibition of platelet n-8 lipoxygenase by 5,8,11-eicosatriynoic acid. Biochim Biophys Acta. 1977 Jun 22;487(3):517-9.
- [2] Kliewer SA, et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell. 1995 Dec 1;83(5):813-9.
- [3] Palumbo GJ, et, al. Inhibitors of the lipoxygenase pathway specifically block orthopoxvirus replication. Virology. 1991 Jan;180(1):457-63.
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