[CAS NO. 119509-24-9] AtpeninA5

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [119509-24-9]

Catalog

HY-126653

Brand

MCE

CAS

119509-24-9

DESCRIPTION [119509-24-9]

Overview

MDL	-
Molecular Weight	366.24
Molecular Formula	C15H21Cl2NO5
SMILES	O=C1C(C([C@@H](C)C[C@H](C)[C@@H](Cl)CCl)=O)=C(O)C(OC)=C(OC)N1

For research use only. We do not sell to patients.

Summary

Atpenin A5 is a potent and highly specific complex II inhibitor ( IC ₅₀ ~10 nM), and is an effective mK _ATP channel agonist and cardioprotective agent ^[1] .

In Vitro

Atpenin A5 shows the inhibition profile for submitochondrial particles (SMPs), mitochondria, and cardiomyocytes, with IC50 values of 8.3, 9.3, and 8.5 nM, respectively. Atpenin A5 (AA5) is a potent and specific complex II inhibitor. Atpenin A5 (1 nM) also activates the mKATP channel and protects against simulated ischemia-reperfusion (IR) injury in isolated cardiomyocytes ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Atpenin A5 is a potent inhibitor of succinate dehydrogenase (SDH). Succinate dehydrogenase inhibition by Atpenin A5 promotes cardiomyocyte mitosis and regeneration in the postnatal heart after myocardial infarction (MI). Atpenin A5-injected mice demonstrated myocardial thickness at the infarct zone and a significant reduction in scar size compared with controls ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Neonatal mice ^[2]
Dosage:	100 μg/kg
Administration:	Injected daily
Result:	Demonstrated myocardial thickness at the infarct zone and a significant reduction in scar size compared with controls.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 273.04 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7304 mL	13.6523 mL	27.3045 mL
5 mM	0.5461 mL	2.7304 mL	5.4609 mL
10 mM	0.2730 mL	1.3652 mL	2.7304 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.83 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (6.83 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.83 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

2(1H)-Pyridinone, 3-[(2S,4S,5R)-5,6-dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-

2(1H)-Pyridinone, 3-(5,6-dichloro-2,4-dimethyl-1-oxohexyl)-4-hydroxy-5,6-dimethoxy-, [2S-(2R*,4R*,5S*)]-

3-[(2S,4S,5R)-5,6-Dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1H)-pyridinone

Atpenin A 5

FO 125A₅

Antibiotic FO 125A₅