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[CAS NO. 1203494-49-8] DASA-58
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-19330 |
| Brand: | MCE |
| CAS: | 1203494-49-8 |
Overview
| MDL | MFCD29472280 |
|---|---|
| Molecular Weight | 453.53 |
| Molecular Formula | C19H23N3O6S2 |
| SMILES | NC1=CC=CC(S(=O)(N2CCN(S(=O)(C3=CC=C(OCCO4)C4=C3)=O)CCC2)=O)=C1 |
12 Publications Citing Use of MCE
- [1]Nature. 2021 Sep;597(7875):263-267.
- [2]Nat Immunol. 2018 Mar;19(3):267-278.
- [3]Nat Commun. 2020 Jun 22;11(1):3162.
- [4]Nat Commun. 2020 Feb 18;11(1):941.
- [5]Cancer Res. 2022 Jul 12;can.21.4222.
- [6]Mucosal Immunol. 2019 Nov;12(6):1280-1290.
- [7]Sci Signal. 2020 Oct 27;13(655):eaay9217.
- [8]J Agric Food Chem. 2022 Dec 5.
- [9]Am J Pathol. 2020 Nov;190(11):2267-2281.
- [10]Arch Biochem Biophys. 2019 Jul 30;670:94-103.
- [11]Drug Des Dev Ther. 2020 May 27;14:2091-2100.
- [12]Animals. 2021 Feb 6;11(2):425.
Summary
DASA-58 is a potential pyruvate kinase isozyme (PKM2) allosteric activator. DASA-58 can be used for the research of metabolism and kinds of cancer [1] .
In Vitro
DASA-58 (15 μM; 2 h) potentiates the antitumor effects of other metabolic stressors
[1]
.
DASA-58 (15 μM; 24 h, 72 h) enhances pyruvate kinase activity in breast cancer cells without a clear effect on proliferation
[1]
.
DASA-58 (30 μM, 60 μM; 0-72 h) enhances extracellular acidification and lactate levels in BCa cell lines and induce extracellular acidification levels in prostate cancer cell lines
[1]
.
DASA-58 (15 μM, 30 μM; 0-72 h) affects respiration levels in BCa cells without an indication of mitochondrial damage
[1]
.
DASA-58 (15 μM; 0-72 h) not rescues TXNIP levels in any combintion and mitochondrial inhibitors enhance PKM2 effects on activating AMPK signaling (T172 phosphorylation of AMPK)
[1]
.
DASA-58 (15 μM; 0-72 h) leads to depletion in TXNIP levels independent of AMPK and ER signaling, and not through enhanced proteasomal degradation but rather depleted upstream glycolytic intermediates
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: |
Five breast cancer cell lines (BCa cells)
(MDA MB 231, MDA MB 468, HCC 1443, T47-D, MCF7, LnCap, PC3, and DU145) |
| Concentration: | 15 μM |
| Incubation Time: | 2 h |
| Result: | Could be exploited by other metabolic stressors. |
Western Blot Analysis [1]
| Cell Line: | BCa cells |
| Concentration: | 15 μM |
| Incubation Time: | 24 h, 72 h |
| Result: |
Showed comparable PKM2 protein levels in five breast cancer cell lines, except HCC1443 cells and MDA MB 468 that showed the highest and lowest PKM2 protein levels, respectively.
Not changed PKM2 levels in five breast cancer cell lines but seemingly reduced TXNIP levels in cells expressing detectable TXNIP levels. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 35 mg/mL ( 77.17 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.2049 mL | 11.0246 mL | 22.0493 mL |
| 5 mM | 0.4410 mL | 2.2049 mL | 4.4099 mL |
| 10 mM | 0.2205 mL | 1.1025 mL | 2.2049 mL |
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