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[CAS NO. 120447-62-3] (±)-Vesamicol hydrochloride
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-B1813A |
| Brand: | MCE |
| CAS: | 120447-62-3 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 295.85 |
| Molecular Formula | C17H26ClNO |
| SMILES | O[C@H]1[C@H](N2CCC(C3=CC=CC=C3)CC2)CCCC1.[H]Cl |
Summary
IC50 & Target
Ki: 2 nM (Vesicular acetylcholine transport), 26 nM (σ1 receptors) and 34 nM (σ2 receptors) [1]
In Vitro
The pharmacological actions of (±)-Vesamicol have been attributed to inhibition of acetylcholine transport into synaptic vesicles and the subsequent quantal release of acetylcholine [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
(±)-Vesamicol (3 mg/kg; intraperitoneal injection; once; male Wistar rats) treatment increases the levels of cytosolic acetylcholine (ACh) in all regions of the brain, while those of vesicular ACh decreased in all regions except for the striatum [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Male Wistar rats (120-300 g) [2] |
| Dosage: | 3 mg/kg |
| Administration: | Intraperitoneal injection; once |
| Result: | The levels of cytosolic acetylcholine (ACh) increased in all regions of the brain, while those of vesicular ACh decreased in all regions except for the striatum. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 20.83 mg/mL ( 70.41 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.3801 mL | 16.9005 mL | 33.8009 mL |
| 5 mM | 0.6760 mL | 3.3801 mL | 6.7602 mL |
| 10 mM | 0.3380 mL | 1.6900 mL | 3.3801 mL |
References
- [1] S M Efange, et al. N-hydroxyalkyl derivatives of 3 beta-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters. J Med Chem. 1997 Nov 21;40(24):3905-14.
- [2] H Kobayashi, et al. Effects of systemic administration of 2-(4-phenyl-piperidino)-cyclohexanol (vesamicol) and an organophosphate DDVP on the cholinergic system in brain regions of rats. Brain Res Bull. 1997;43(1):17-23.
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