[CAS NO. 1208229-58-6] Tepilamide fumarate
PRODUCTS SPECIFICATIONS [1208229-58-6]
DESCRIPTION [1208229-58-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 243.26 |
| Molecular Formula | C11H17NO5 |
| SMILES | O=C(OCC(N(CC)CC)=O)/C=C/C(OC)=O |
Summary
Tepilamide fumarate (XP-23829; PPC-06) is an oral fumaric acid ester, acts as a prodrug of Monomethyl fumarate (HY-103252), and is used in the research of moderate to severe chronic plaque psoriasis [1] .
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT02173301 | Dr. Reddy´s Laboratories Limited|XenoPort, Inc. |
Psoriasis
|
June 2014 | Phase 2 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 125 mg/mL ( 513.85 mM )
H 2 O : 50 mg/mL ( 205.54 mM ; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.1108 mL | 20.5541 mL | 41.1083 mL |
| 5 mM | 0.8222 mL | 4.1108 mL | 8.2217 mL |
| 10 mM | 0.4111 mL | 2.0554 mL | 4.1108 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 25 mg/mL (102.77 mM); Clear solution; Need ultrasonic
-
2.
-
3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (8.55 mM); Clear solution
-
4.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (8.55 mM); Clear solution