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[CAS NO. 120964-45-6] 3-Deazaneplanocin A hydrochloride
| Ships within | Stock | Price | Qty | Total |
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| Catalog: | HY-12186G |
| Brand: | MCE |
| CAS: | 120964-45-6 |
Overview
| MDL | MFCD18782644 |
|---|---|
| Molecular Weight | 298.73 |
| Molecular Formula | C12H15ClN4O3 |
| SMILES | O[C@@H]1[C@H](O)C(CO)=C[C@H]1N2C=NC3=C2C=CN=C3N.[H]Cl |
6 Publications Citing Use of MCE
- [1]Nat Commun. 2022 Jan 10;13(1):12.
- [2]Apoptosis. 2020 Oct;25(9-10):697-714.
- [3]J Pharmacol Exp Ther. 2019 Sep;370(3):490-503.
- [4]Biochem Biophys Res Commun. 2018 Sep 10;503(3):2061-2067.
- [5]Exp Mol Pathol. 2020 Feb;112:104344.
- [6]Università degli Studi di CAGLIARI. Dipartimento di Scienze Biomediche. 2021 May.
Summary
3-Deazaneplanocin A (DZNep) hydrochloride (GMP) is 3-Deazaneplanocin A hydrochloride (HY-12186) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. 3-Deazaneplanocin A hydrochloride is a potent histone methyltransferase EZH2 inhibitor [1] [2] .
IC50 & Target
|
EZH2
|
In Vitro
3-Deazaneplanocin A (20-200 nM, during 16-28 day) stimulates Oct4 expression in chemically induced pluripotent stem cells (CiPSCs)
[2]
.
3-Deazaneplanocin A (20-200 nM, during 16-28 day) inhibits DNA and H3K9 methylation at the Oct4 promoter in CiPSCs
[2]
.
3-Deazaneplanocin A (10 nM, 24 h) promotes developmental competence of cloned pig embryos
[3]
.
3-Deazaneplanocin A (10 nM, 24 h) decreases the levels of H3K27me3 and H3K9me2 at the 2-cell, 4-cell and blastocyst stages
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Immunofluorescence [3]
| Cell Line: | Cloned pig embryos |
| Concentration: | 10 nM |
| Incubation Time: | 24 h |
| Result: | Decreased H3K27me3 and H3K9me2 by approximately 45%, 37% and 7% at the 2-cell, 4-cell and blastocyst stages, respectively. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Fiskus W, et al. Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells. Blood. 2009 Sep 24;114(13):2733-43.
- [2] Hou P, et al. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science. 2013 Aug 9;341(6146):651-4.
- [3] Zhao C, et al. DZNep and UNC0642 enhance in vitro developmental competence of cloned pig embryos. Reproduction. 2018 Apr 1;157(4):359-369.
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