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[CAS NO. 12141-67-2] Sodium metatungstate
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-103259 |
| Brand: | MCE |
| CAS: | 12141-67-2 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 2986.01 |
| Molecular Formula | H2Na6O40W12 |
| SMILES | [3Na2WO4.9WO3] |
4 Publications Citing Use of MCE
Summary
Sodium metatungstate (Sodium polyoxotungstate) is a potent ecto-nucleoside triphosphate diphosphohydrolase (ENTPDase) inhibitor, with K i values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively [1] . Sodium metatungstate inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition [2] .
IC50 & Target
Ki: 2.58 μM (NTPDase 1), 3.26 μM (NTPDase 3), 28.8 μM (NTPDase 2) [1] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 50 mg/mL ( 16.74 mM ; Need ultrasonic)
DMSO : 50 mg/mL ( 16.74 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.3349 mL | 1.6745 mL | 3.3490 mL |
| 5 mM | 0.0670 mL | 0.3349 mL | 0.6698 mL |
| 10 mM | 0.0335 mL | 0.1674 mL | 0.3349 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (33.49 mM); Clear solution; Need ultrasonic
-
2.
-
3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (0.84 mM); Clear solution
-
4.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (0.84 mM); Clear solution
References
- [1] Müller CE, et al. Polyoxometalates--a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5943-7.
- [2] Wall et al. The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. Neuropharmacology. 2008 Dec;55(7):1251-8.
Synonyms
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