[CAS NO. 1217338-97-0] BMS-929075
PRODUCTS SPECIFICATIONS [1217338-97-0]
DESCRIPTION [1217338-97-0]
Overview
| MDL | MFCD31556637 |
|---|---|
| Molecular Weight | 538.54 |
| Molecular Formula | C31H24F2N4O3 |
| SMILES | O=C(C1=CC(C2=C(F)C3=C(OC(C4=CC=C(F)C=C4)=C3C(NC)=O)C=C2)=C(C)C=C1)NC5(CC5)C6=NC=CC=N6 |
Summary
In Vitro
BMS-929075 (0-60 µM) shows cytotoxicity with CC 50 values of 60, >12.5, >50 µM for Huh-7, HepG2, primary human hepatocytes, respectively [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
BMS-929075 (compound 37) (2 mg/kg for i.v.; 6 mg/kg for p.o.) shows good pharmacokinetic parameters with oral bioavailability of 48% in rats
[1]
.
Pharmacokinetic Parameters of BMS-929075 in Male Sprague-Dawley rats
[1]
.
| IV | PO | |||||||||
| species | Cl (mL/min/kg) | IV t 1/2 (hr) | V ss (L/kg) | C max (µM) | T max (hr) | AUC (µM h) | C6 liver (µM) | C24 liver (µM) | C24 liver/plasma (µM) | F% (mL/min/kg) |
| rat | 1.7 | 4.7 | 0.7 | 7.5 | 4 | 54.5 | 15.1 | 1.12 | 1.6 | 48 |
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.