[CAS NO. 1224431-15-5] MFZ 10-7

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PRODUCTS SPECIFICATIONS [1224431-15-5]

Catalog

HY-103575

Brand

MCE

CAS

1224431-15-5

DESCRIPTION [1224431-15-5]

Overview

MDL	-
Molecular Weight	236.24
Molecular Formula	C15H9FN2
SMILES	N#CC1=CC(C#CC2=NC(C)=CC=C2)=CC(F)=C1

For research use only. We do not sell to patients.

Summary

MFZ 10-7 is a potent mGluR5 antagonist. Intraperitoneal administration of MFZ 10-7 inhibits intravenous cocaine self-administration, cocaine-induced reinstatement of drug-seeking behavior and cocaine-associated cue-induced cocaine-seeking behavior in rats ^[1] ..

IC50 & Target

mGluR5 ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 17.86 mg/mL ( 75.60 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.2330 mL	21.1649 mL	42.3298 mL
5 mM	0.8466 mL	4.2330 mL	8.4660 mL
10 mM	0.4233 mL	2.1165 mL	4.2330 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Keck TM, et al. A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats. Addict Biol.