[CAS NO. 1228817-38-6] Mps1-IN-2
PRODUCTS SPECIFICATIONS [1228817-38-6]
DESCRIPTION [1228817-38-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 480.60 |
| Molecular Formula | C26H36N6O3 |
| SMILES | CN(C1=CN=C(NC2=C(OCC)C=C(N3CCC(O)CC3)C=C2)N=C1N(C4CCCC4)CC5)C5=O |
Summary
IC50 & Target
|
Mps1 12 nM (Kd) |
GAK 140 nM (Kd) |
PLK1 61 nM (Kd) |
PLK3 1600 nM (Kd) |
PLK4 3100 nM (Kd) |
STK33 5000 nM (Kd) |
In Vitro
Mps1-IN-2 is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC 50 and a K d of 145 nM and 12 nM. Mps1-IN-2 also shows high affinity for PLK1 and GAK with K d s of 61 and 140 nM, respectively, but shows little or no inhibition on other 352 member kinases. Mps1-IN-2 can induces bypass of a checkpoint-mediated mitotic arrest in U2OS cells [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 13.33 mg/mL ( 27.74 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.0807 mL | 10.4037 mL | 20.8073 mL |
| 5 mM | 0.4161 mL | 2.0807 mL | 4.1615 mL |
| 10 mM | 0.2081 mL | 1.0404 mL | 2.0807 mL |