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[CAS NO. 1233339-22-4] AZ20
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-15557 |
| Brand: | MCE |
| CAS: | 1233339-22-4 |
Overview
| MDL | MFCD25976730 |
|---|---|
| Molecular Weight | 412.51 |
| Molecular Formula | C21H24N4O3S |
| SMILES | O=S(C1(C2=CC(N3[C@H](C)COCC3)=NC(C4=CC=CC5=C4C=CN5)=N2)CC1)(C)=O |
10 Publications Citing Use of MCE
- [1]Mol Cell. 2021 Mar 4;81(5):1084-1099.e6.
- [2]Nat Commun. 2022 Nov 28;13(1):7212.
- [3]Nat Commun. 2019 Jul 2;10(1):2910.
- [4]Cell Syst. 2020 Jan 22;10(1):66-81.e11.
- [5]Cell Syst. 2020 Jan 22;10(1):66-81.e11.
- [6]Cell Death Dis. 2017 Aug 10;8(8):e2982.
- [7]J Mol Med (Berl). 2019 Aug;97(8):1183-1193.
- [8]Life Sci Alliance. 2020 Feb 18;3(4):e201900427.
- [9]Life Sci Alliance. 2020 Jun 22;3(8):e202000671.
- [10]Harvard Medical School LINCS LIBRARY
Summary
IC50 & Target
|
ATR 5 nM (IC 50 ) |
mTOR 38 nM (IC 50 ) |
PI3Kα 13000 nM (IC 50 ) |
In Vitro
AZ20 inhibits ATR immunoprecipitated from HeLa nuclear extracts with an IC 50 of 5 nM and ATR mediated phosphorylation of Chk1 in HT29 colorectal adenocarcinoma tumor cells with an IC 50 of 50 nM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
AZ20 (25, 50 mg/kg, p.o.) has high permeability combined with good stability to rat hepatocytes and, despite the lack of progress in achieving markedly higher solubility, has respectable bioavailability in a low dose rat PK study. AZ20 (25, 50 mg/kg, p.o.) leads to significant tumor growth inhibition in female nude mice bearing LoVo tumors [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 242.42 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4242 mL | 12.1209 mL | 24.2418 mL |
| 5 mM | 0.4848 mL | 2.4242 mL | 4.8484 mL |
| 10 mM | 0.2424 mL | 1.2121 mL | 2.4242 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (6.06 mM); Clear solution
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