[CAS NO. 1235034-55-5] A-1155463

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PRODUCTS SPECIFICATIONS [1235034-55-5]

Catalog

HY-19725

Brand

MCE

CAS

1235034-55-5

DESCRIPTION [1235034-55-5]

Overview

MDL	MFCD29924714
Molecular Weight	669.79
Molecular Formula	C35H32FN5O4S2
SMILES	O=C(C1=C(CCCOC2=CC=C(C#CCN(C)C)C=C2F)SC(N3CC4=C(C=CC=C4C(NC5=NC6=CC=CC=C6S5)=O)CC3)=N1)O

For research use only. We do not sell to patients.

10 Publications Citing Use of MCE

Summary

A-1155463 is a highly potent and selective BCL-XL inhibitor with an EC ₅₀ of 70 nM in Molt-4 cell.

IC50 & Target

Bcl-xL

0.01 nM (Ki)

Bcl-2

80 nM (Ki)

In Vitro

A-1155463 shows picomolar binding affinity to BCL-X _L (K _i ＜0.01 nM), and >1000-fold weaker binding to BCL-2 (K _i = 80 nM) and related proteins BCL-W (K _i = 19 nM) and MCL-1 (K _i > 440 nM) ^[2] . A-1155463 demonstrates strong growth inhibition of over half of the colorectal cell lines as defined by EC ₅₀ values ≤0.5 μM in the presence of 10 % FBS ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

A-1155463 caused a mechanism-based and reversible thrombocytopenia in mice and inhibited H146 small cell lung cancer xenograft tumor growth in vivo following multiple doses ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 12.5 mg/mL ( 18.66 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4930 mL	7.4650 mL	14.9301 mL
5 mM	0.2986 mL	1.4930 mL	2.9860 mL
10 mM	0.1493 mL	0.7465 mL	1.4930 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 1.25 mg/mL (1.87 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 1.25 mg/mL (1.87 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: 1.25 mg/mL (1.87 mM); Clear solution; Need ultrasonic

* All of the co-solvents are available by MCE.