[CAS NO. 1236767-85-3] D5D-IN-326
PRODUCTS SPECIFICATIONS [1236767-85-3]
DESCRIPTION [1236767-85-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 473.27 |
| Molecular Formula | C17H11F8N3O4 |
| SMILES | O=C1C2=C(N=C(N1C3=CC=C(C=C3)OCC(F)(F)F)OCC(F)(C(F)(F)F)F)NC(C2)=O |
Summary
D5D-IN-326 is a selective, orally active delta-5 desaturase (D5D) inhibitor, with IC 50 s of 72 and 22 nM for rat and human D5D in enzymic and cell-based assays, respectively, has no effect on D6D or D9D activity. D5D-IN-326 reduces insulin resistance and decreases body weight in diet-induced obese C57BL/6J mice [1] .
IC50 & Target
IC50: 72 nM (Rat D5D), 22 nM (Human D5D) [1]
In Vitro
D5D-IN-326 is a selective, orally active delta-5 desaturase (D5D) inhibitor, with IC 50 s of 72 and 22 nM for rat and human D5D in enzymic and cell-based assays, respectively, has no effect on D6D or D9D activity [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
D5D-IN-326 (0.1, 1, and 10 mg/kg, p.o. for 6 weeks) gradually decreases body weight at 10 mg/kg, but lowers doses are not effective in DIO mice after treatment for 6 weeks
[1]
.
D5D-IN-326 (10 mg/kg, p.o. for 6 weeks) also significantly decreases gene expression levels of
Ccl2
,
Cd68
,
Adgre1
, and
Il6
, decreases epididymal
Lep
and
Adipoq
mRNAs which are significantly increased in HFD DIO mice
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 125 mg/mL ( 264.12 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1130 mL | 10.5648 mL | 21.1296 mL |
| 5 mM | 0.4226 mL | 2.1130 mL | 4.2259 mL |
| 10 mM | 0.2113 mL | 1.0565 mL | 2.1130 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (4.39 mM); Clear solution