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[CAS NO. 1243245-18-2] GNF-6231
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-100408 |
| Brand: | MCE |
| CAS: | 1243245-18-2 |
Overview
| MDL | MFCD30343851 |
|---|---|
| Molecular Weight | 448.49 |
| Molecular Formula | C24H25FN6O2 |
| SMILES | O=C(NC1=NC=C(N2CCN(C(C)=O)CC2)C=C1)CC3=CN=C(C4=CC(F)=NC=C4)C(C)=C3 |
Summary
GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling. 1) GNF-6231 shows IC50s of greater than 10 μM on all CYP isoforms tested 2) GNF-6231 have favorable potency and a PK profile across preclinical species upon oral administration. 3) The reference for orally in MMTV-Wnt1 tumor bearing mice is dosed at 3 mg/kg. 4) GNF-6231 showed very robust dose-related antitumor efficacy.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 36 mg/mL ( 80.27 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.2297 mL | 11.1485 mL | 22.2970 mL |
| 5 mM | 0.4459 mL | 2.2297 mL | 4.4594 mL |
| 10 mM | 0.2230 mL | 1.1149 mL | 2.2297 mL |
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