[CAS NO. 125-10-0] Prednisone acetate

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PRODUCTS SPECIFICATIONS [125-10-0]

Catalog

HY-B1832

Brand

MCE

CAS

125-10-0

DESCRIPTION [125-10-0]

Overview

MDL	-
Molecular Weight	400.46
Molecular Formula	C23H28O6
SMILES	C[C@@]1(C2)[C@](C(COC(C)=O)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3([H])C2=O)=O

For research use only. We do not sell to patients.

Summary

Prednisone acetate (Prednisone 21-acetate), the acetate salt form of prednisolone, is a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties ^[1] .

IC50 & Target

glucocorticoid receptor ^[1]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT04501367	Kovach Eye Institute	Vitrectomy\|Macular Pucker\|Retinal Edema	August 20, 2020	Phase 4
NCT04869488	Jiangsu HengRui Medicine Co., Ltd.	Metastatic Castration Resistant Prostate Cancer	July 26, 2021	Phase 2
NCT03591471	Henan University of Traditional Chinese Medicine\|Peking University First Hospital\|Children´s Hospital of Fudan University\|Shanghai Children´s Hospital\|Chengdu University of Traditional Chinese Medicine\|Affiliated Hospital of Yunnan University of Traditional Chinese Medicine	Henoch-Schönlein Purpura Nephritis	September 2014	Phase 1\|Phase 2
NCT02981979	Jiang lindi\|Shanghai Zhongshan Hospital	Takayasu Arteritis	December 2016	Not Applicable
NCT04992026	The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School\|The Affiliated Hospital of Xuzhou Medical University\|The First People´s Hospital of Changzhou\|The First Affiliated Hospital of Soochow University\|Wuxi People´s Hospital\|The Affiliated Hospital of Nantong University\|The Affiliated Hospital of Yangzhou University	Prostatectomy\|Oligometastatic Prostate Cancer\|Abiraterone	January 1, 2021	Phase 2
NCT04658927	Warrenville Eyecare	Meibomian Gland Dysfunction\|Evaporative Dry Eye	January 4, 2021	Phase 4
NCT04869371	Hongqian Guo\|The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School	Neoadjuvant Therapy High Risk Prostate Cancer Docetaxel	December 12, 2018	Phase 2
NCT05405439	Chia Tai Tianqing Pharmaceutical Group Co., Ltd.	Metastatic Castration-resistant Prostate Cancer	June 2022	Phase 1\|Phase 2

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL ( 62.43 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4971 mL	12.4856 mL	24.9713 mL
5 mM	0.4994 mL	2.4971 mL	4.9943 mL
10 mM	0.2497 mL	1.2486 mL	2.4971 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.24 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (5.19 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (5.19 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Prednisolone acetate

Synonyms

Pregna-1,4-diene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy-

Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-, 21-acetate

21-(Acetyloxy)-17-hydroxypregna-1,4-diene-3,11,20-trione

21-Acetoxy-17α-hydroxypregna-1,4-diene-3,11,20-trione

Δ¹-Cortisone 21-acetate

Delcortin

Delta-Corlin

Deltalone

Ferrosan

Nisone

Prednisone acetate

Prednisone 21-acetate

Cortancyl

Δ¹-Dehydrocortisone acetate

NSC 10965