[CAS NO. 1253186-49-0] GSK-5498A
PRODUCTS SPECIFICATIONS [1253186-49-0]
DESCRIPTION [1253186-49-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 399.29 |
| Molecular Formula | C18H11F6N3O |
| SMILES | O=C(NC1=NN(CC2=C(F)C=CC=C2C(F)(F)F)C=C1)C3=C(F)C=CC=C3F |
3 Publications Citing Use of MCE
Summary
GSK-5498A is a selective CARC channel inhibitor ( IC 50 : 1 μM). GSK-5498A inhibits mediators release from mast cells and pro-inflammatory cytokines release from T cells. GSK-5498A can be used in the research of inflammatory disorders [1] .
IC50 & Target
CRAC channel [1]
In Vitro
GSK-5498A (1 and 10 μM) inhibits calcium influx through CRAC channels in human embryonic kidney cells
[1]
.
GSK-5498A (1 nM-10 μM) inhibits the thapsigargin-evoked fluorescence signal (pIC
50
: 6.3) in Jurkat cells, measured using the calcium sensitive dye: Fluo4-AM
[1]
.
GSK-5498A (1 nM-10 μM) evokes concentration-dependent inhibition of Cytostim-evoked interferon-γ and IL-5 production in PBMCs
[1]
.
GSK-5498A (1 μM-10 μM) inhibits degranulation of rat tissue-resident mast cells
[1]
.
GSK-5498A (10 nM-10 μM) inhibits mouse and rat T-cell cytokine (IL-2) release
[1]
.
GSK-5498A (0-10 μM) shows high selectivity for CRAC channels over other ion channels, enzymes and G-protein coupled receptors
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 250.44 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.5044 mL | 12.5222 mL | 25.0445 mL |
| 5 mM | 0.5009 mL | 2.5044 mL | 5.0089 mL |
| 10 mM | 0.2504 mL | 1.2522 mL | 2.5044 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 3 mg/mL (7.51 mM); Clear solution