[CAS NO. 1257705-09-1] GS-829845

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PRODUCTS SPECIFICATIONS [1257705-09-1]

Catalog

HY-W394903

Brand

MCE

CAS

1257705-09-1

DESCRIPTION [1257705-09-1]

Overview

MDL	MFCD31382011
Molecular Weight	357.43
Molecular Formula	C17H19N5O2S
SMILES	O=S1(CCN(CC1)CC2=CC=C(C3=CC=CC4=NC(N)=NN43)C=C2)=O

For research use only. We do not sell to patients.

Summary

GS-829845 is a major, active metabolite of Filgotinib (HY-18300). GS-829845 is a JAK1 preferential inhibitor but is approximately 10-fold less potent than the parent and with a longer half-life ^[1] ^[2] .

IC50 & Target

JAK1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] Amy Meng, et al. Exposure-response relationships for the efficacy and safety of filgotinib and its metabolite GS-829845 in subjects with rheumatoid arthritis based on phase 2 and phase 3 studies. Br J Clin Pharmacol. 2022 Jul;88(7):3211-3221.
[2] Chia-Hsiang Hsueh, et al. Evaluation of the potential drug interactions mediated through P-gp, OCT2, and MATE1/2K with filgotinib in healthy subjects. Clin Transl Sci. 2022 Feb;15(2):361-370.