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[CAS NO. 126-17-0] Solasodine
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-N0068 |
| Brand: | MCE |
| CAS: | 126-17-0 |
Overview
| MDL | MFCD00037844 |
|---|---|
| Molecular Weight | 413.64 |
| Molecular Formula | C27H43NO2 |
| SMILES | C[C@H](CC1)CN[C@]21O[C@@]3([H])C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@@]3([H])[C@@H]2C |
1 Publications Citing Use of MCE
Summary
Solasodine (Purapuridine) is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities [1] [2] .
In Vitro
Solasodine (90 μM; 2 days) treatment displays significant sprouting in P19 cells. Solasodine induces strong expression of the different neuronal markers studied, including βIII-tubulin, synaptophysin, MAP2, ChAT, and neuroblast marker doublecortin. Solasodine induces the differentiation of P19 cells, essentially towards the neuronal pathway [1] . Solasodine induce apoptosis by inhibiting the p53-MDM2 complex, p21 Waf1/Cip1 , and Bcl-2 proteins [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Solasodine (25-100 mg/kg; intraperitoneal injection; once) treatment significantly delays latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. And significantly potentiates Thiopental-provoked sleep in a dose-dependent manner. Solasodine has anticonvulsant and CNS depressant activities
[2]
.
Solasodine (375 μM; i.c.v.; for 2 weeks) treatment results a significant increase in bromodeoxyuridine uptake by cells of the ependymal layer, subventricular zone, and cortex that co-localized with doublecortin immunostaining. Solasodine treatment in rats results in a dramatic increase in expression of the cholesterol- and drug-binding translocator protein in ependymal cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Swiss albino mice (18-25 g) treated with Picrotoxin (PCT) or Thiopental [2] |
| Dosage: | 25 mg/kg, 50 mg/kg and 100 mg/kg |
| Administration: | Intraperitoneal injection; once |
| Result: | Significantly delayed latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. And significantly potentiated Thiopental-provoked sleep in a dose-dependent manner. |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT04693000 | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh |
Keratotic Nodular Size
|
September 23, 2018 | Phase 2 |
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 2.6 mg/mL ( 6.29 mM ; Need ultrasonic)
H 2 O : 0.67 mg/mL ( 1.62 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4176 mL | 12.0878 mL | 24.1756 mL |
| 5 mM | 0.4835 mL | 2.4176 mL | 4.8351 mL |
| 10 mM | --- | --- | --- |
References
- [1] Lecanu L, et al. The naturally occurring steroid solasodine induces neurogenesis in vitro and in vivo. Neuroscience. 2011 Jun 2;183:251-64.
- [2] Chauhan K, et al. Anticonvulsant activity of solasodine isolated from Solanum sisymbriifolium fruits in rodents. Pharm Biol. 2011 Feb;49(2):194-9.
- [3] Akhtar S, et al. Evaluation and Elucidation Studies of Natural Aglycones for Anticancer Potential using Apoptosis-Related Markers: An In silico Study. Interdiscip Sci. 2018 Jun;10(2):297-310.
- [4] Gupta RS, et al. Effects of short-term treatment of solasodine on cauda epididymis in dogs. Indian J Exp Biol. 2002 Feb;40(2):169-73.
Synonyms
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