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[CAS NO. 130-95-0] Quinine
| Ships within | Stock | Price | Qty | Total |
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| Catalog: | HY-D0143 |
| Brand: | MCE |
| CAS: | 130-95-0 |
Overview
| MDL | MFCD00198096 |
|---|---|
| Molecular Weight | 324.42 |
| Molecular Formula | C20H24N2O2 |
| SMILES | O[C@H](C1=CC=NC2=C1C=C(OC)C=C2)[C@@]3([H])[N@](C[C@@H]4C=C)CC[C@H]4C3 |
2 Publications Citing Use of MCE
Summary
Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (K Ca 5.1) channel currents evoked by voltage pulses to +100 mV with an IC 50 of 169 μM [1] [2] .
In Vitro
Quinine (150 μM, 30 min) inhibits the proliferation and cytostatic effects of DENV (Dengue virus) in human hepatocarcinoma HepG2 cell line
[1]
.
Quinine (37.5-150 μM, 24 hours) significantly reduces viral DENV RNA and protein levels in a dose-dependent manner in human hepatocarcinoma HepG2 cell line
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay [1]
| Cell Line: | Human hepatocarcinoma cell line (HepG2) |
| Concentration: | 150 μM |
| Incubation Time: | 30 min |
| Result: | Inhibited DENV virus replication with 19% yield compared to untreated. Reduced DENV-positive cells from 23.28% to 12.05% in a dose-dependent manner. |
In Vivo
Quinine (oral gavage, 12 or 15 mg/kg, every week, 16 weeks) has some tumor suppressing effect on skin cancer in Swiss albino mice
[2]
.
Quinine (oral gavage, 10 mg/kg, everyday, 8 weeks) causes a decrease in the antioxidant defense system of rat testicular tissue such as SOD, CAT and GSH enzyme activity in male adult albino rats
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Swiss albino mice 7-8-weeks (weighing 24 g) [2] |
| Dosage: | 12 mg/kg, 15 mg/kg |
| Administration: | Oral gavage; every week; 16 weeks |
| Result: | Resulted in a significant reduction in tumor size and weight at 12 mg/kg and little effect at higher dose of 15 mg/kg. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 308.24 mM )
H 2 O : 0.1 mg/mL ( 0.31 mM ; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.0824 mL | 15.4121 mL | 30.8242 mL |
| 5 mM | 0.6165 mL | 3.0824 mL | 6.1648 mL |
| 10 mM | 0.3082 mL | 1.5412 mL | 3.0824 mL |
References
- [1] Jhanwar, Deepika，et al. Chemoprevention of DMBA induced skin carcinogenesis in swiss albino mice by quinine sulfate.(2016): 2636-2640.
- [2] Shilu Malakar，et al. Drug repurposing of quinine as antiviral against dengue virus infection. Virus Res. 2018 Aug 15;255:171-178. doi: 10.1016/j.virusres.2018.07.018. Epub 2018 Jul 25.
- [3] Ebenezer O Farombi, et al. Quercetin protects against testicular toxicity induced by chronic administration of therapeutic dose of quinine sulfate in rats. J Basic Clin Physiol Pharmacol. 2012 Feb 27;23(1):39-44.
- [4] Jane Achan , et al. Quinine, an Old Anti-Malarial Drug in a Modern World: Role in the Treatment of Malaria. Malar J. 2011 May 24;10:144.
- [5] Wrighton DC, et al. Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium. Br J Pharmacol. 2015 Sep;172(17):4355-63.
Synonyms
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