[CAS NO. 1303607-07-9] MI-773

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PRODUCTS SPECIFICATIONS [1303607-07-9]

Catalog

HY-17493

Brand

MCE

CAS

1303607-07-9

DESCRIPTION [1303607-07-9]

Overview

MDL	MFCD28168022
Molecular Weight	562.50
Molecular Formula	C29H34Cl2FN3O3
SMILES	O=C([C@H](N[C@@H]1CC(C)(C)C)[C@H](C2=CC=CC(Cl)=C2F)[C@]31C(NC4=C3C=CC(Cl)=C4)=O)N[C@H]5CC[C@H](O)CC5

For research use only. We do not sell to patients.

3 Publications Citing Use of MCE

Summary

MI-773 is a potent MDM2-p53 protein‐protein interaction (PPI) inhibitor with high binding affinity against MDM2 (K _d =8.2 nM). MI-773 has antitumor activity ^[1] ^[2] .

In Vitro

SAR405838 (MI-77301), an analog of MI-773, displays 10 times higher binding affinity against MDM2 than MI-773 (K _d =62 vs 8.2 nM). The antitumor activity of MI-77301 is more pronounced in a set of wild type p53 xenograft models than MI-773, including SJSA-1 osteosarcoma, human prostate, melanoma, colorectal tumor, LNCAP human prostate tumor and human acute lymphoblastic leukemia ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : ≥ 53 mg/mL ( 94.22 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7778 mL	8.8889 mL	17.7778 mL
5 mM	0.3556 mL	1.7778 mL	3.5556 mL
10 mM	0.1778 mL	0.8889 mL	1.7778 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (4.44 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (4.44 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (4.44 mM); Clear solution

* All of the co-solvents are available by MCE.