[CAS NO. 13071-11-9] (R)-Propranololhydrochloride

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [13071-11-9]

Catalog

HY-A0295

Brand

MCE

CAS

13071-11-9

DESCRIPTION [13071-11-9]

Overview

MDL	-
Molecular Weight	295.80
Molecular Formula	C16H22ClNO2
SMILES	O[C@@H](COC1=C2C=CC=CC2=CC=C1)CNC(C)C.[H]Cl

For research use only. We do not sell to patients.

Summary

(R)-Propranolol hydrochloride is a less active enantiomer of the β-adrenoceptor antagonist propranolol (HY-B0573). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β ₁ AR and β ₂ AR with K _i values of 1.8 nM and 0.8 nM, respectively ^[1] .

In Vivo

Both isomers of propranolol are capable of preventing adrenaline-induced cardiac arrhythmias in cats anaesthetized with halothane, but the mean dose of (-)-propranolol is 0.09 mg/kg whereas that of (+)-propranolol is 4.2 mg/kg ^[1] .
Both isomers of propranolol are capable of reversing ventricular tachycardia caused by ouabain in anaesthetized cats and dogs. The dose of (-)-propranolol is significantly smaller than that of (+)-propranolol ((R)-Propranolol) in both species ^[1] .
(R)-Propranolol hydrochloride (10 mg/kg) has no antagonistic activity in rats, the cardiac responses to isoprenaline of rat can be blocked by probably much less than 1/100th of that of the (-) isomer in this preparation ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 845.17 mM ; Need ultrasonic)

H ₂ O : 7.14 mg/mL ( 24.14 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3807 mL	16.9033 mL	33.8066 mL
5 mM	0.6761 mL	3.3807 mL	6.7613 mL
10 mM	0.3381 mL	1.6903 mL	3.3807 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: PBS

Solubility: 10 mg/mL (33.81 mM); Clear solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (7.03 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (7.03 mM); Clear solution
4.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (7.03 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] A M Barrett,et al. The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias. Br J Pharmacol

Synonyms

2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride (1:1), (2R)-

2-Propanol, 1-(isopropylamino)-3-(1-naphthyloxy)-, hydrochloride, (+)-

2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride, (R)-

2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride, (2R)-

(+)-Propranolol hydrochloride

d-Propranolol hydrochloride

(+)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride

Dexpropranolol hydrochloride

AY 20694

R-(+)-1-Isopropylamino-3-(1-naphthoxy)-2-propanol hydrochloride

ICI 47319

d-Anapriline

(R)-(+)-Propranolol hydrochloride

(R)-Propranolol hydrochloride

(+)-Anapriline

(R)-1-(Isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol hydrochloride