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[CAS NO. 130849-58-0] Z-321
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-19123 |
| Brand: | MCE |
| CAS: | 130849-58-0 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 344.47 |
| Molecular Formula | C19H24N2O2S |
| SMILES | O=C([C@H]1N(C(CC2CC3=C(C=CC=C3)C2)=O)CSC1)N4CCCC4 |
Summary
Z-321 is a prolylendopeptidase ( PEP ) inhibitor.
IC50 & Target
PEP [1]
In Vivo
Z-321 is a prolylendopeptidase (PEP) inhibitor. In the 100 or 200 mg/kg Z-321-treated groups, mean lordosis quotient (LQ) decreases after administration. However, there is no statistical difference among the values before and after. In contrast, the mean LQ in the 300 mg/kg Z-321-treated females is lower than that before injection (P<0.005). Furthermore, when compare to that in the vehicle-treated control group, mean LQ is also significantly lower (p<0.05). The incidence of soliciting behavior decreases after treatment with 300 mg/kg Z-321, when compare to that before treatment, but there is no statistical difference. The present study also demonstrates that 300 mg/kg Z-321 is effective in inhibiting lordosis behavior without disturbance of locomotor activity [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 250 mg/mL ( 725.75 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9030 mL | 14.5151 mL | 29.0301 mL |
| 5 mM | 0.5806 mL | 2.9030 mL | 5.8060 mL |
| 10 mM | 0.2903 mL | 1.4515 mL | 2.9030 mL |
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