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[CAS NO. 1312547-19-5] Samatasvir
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-16784 |
| Brand: | MCE |
| CAS: | 1312547-19-5 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 885.06 |
| Molecular Formula | C47H48N8O6S2 |
| SMILES | O=C(OC)N[C@H](C1=CC=CC=C1)C(N2[C@H](C3=NC=C(C4=CC=C(C5=CSC6=C5SC=C6C7=CC=C8N=C([C@H]9N(C([C@@H](NC(OC)=O)C(C)C)=O)CCC9)NC8=C7)C=C4)N3)CCC2)=O |
Summary
In Vitro
Samatasvir (IDX719) retains full activity in the presence of HIV and hepatitis B virus (HBV) antivirals and is not cross-resistant with HCV protease, nucleotide, and nonnucleoside polymerase inhibitor classes [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT01508156 | Merck Sharp & Dohme LLC |
Hepatitis C, Chronic
|
January 2012 | Phase 1|Phase 2 |
| NCT01813513 | Merck Sharp & Dohme LLC |
Chronic Hepatitis C Infection
|
January 2013 | Phase 1 |
| NCT01335607 | Merck Sharp & Dohme LLC |
Hepatitis C
|
April 2011 | Phase 1 |
| NCT01919125 | Merck Sharp & Dohme LLC |
Hepatitis C, Chronic
|
August 2013 | Phase 1 |
| NCT01813552 | Merck Sharp & Dohme LLC |
Chronic Hepatitis C Infection
|
February 2013 | Phase 1 |
| NCT01907724 | Merck Sharp & Dohme LLC|Janssen Research & Development, LLC |
Hepatitis C, Chronic
|
May 2013 | Phase 1 |
| NCT01852604 | Merck Sharp & Dohme LLC|Janssen Research & Development, LLC |
Chronic Hepatitis C Virus
|
March 2013 | Phase 2 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL ( 56.49 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.1299 mL | 5.6493 mL | 11.2987 mL |
| 5 mM | 0.2260 mL | 1.1299 mL | 2.2597 mL |
| 10 mM | 0.1130 mL | 0.5649 mL | 1.1299 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: 2.5 mg/mL (2.82 mM); Suspended solution; Need ultrasonic
Synonyms
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