[CAS NO. 1314594-23-4] PKR-IN-C51

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PRODUCTS SPECIFICATIONS [1314594-23-4]

Catalog

HY-118131

Brand

MCE

CAS

1314594-23-4

DESCRIPTION [1314594-23-4]

Overview

MDL	-
Molecular Weight	367.45
Molecular Formula	C23H21N5
SMILES	CC(NC1=C2C=CC=C1)=C2C3=NC(NCCC4=CNC5=C4C=CC=C5)=NC=C3

For research use only. We do not sell to patients.

Summary

PKR-IN-C51(compound 51) is an ATP-competitive double-stranded RNA-activated protein kinase (PKR) inhibitor with an IC ₅₀ of 9 μM. PKR-IN-C51 inhibits intracellular PKR activation in a dose-dependent manner in primary mouse macrophages ^[1] .

IC50 & Target

IC50: 9 μM (double-stranded RNA-activated protein kinase (PKR)) ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 340.18 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7215 mL	13.6073 mL	27.2146 mL
5 mM	0.5443 mL	2.7215 mL	5.4429 mL
10 mM	0.2721 mL	1.3607 mL	2.7215 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (5.66 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (5.66 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Ruslana Bryk, et al. Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4108-14.