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[CAS NO. 1314883-11-8] MMV390048
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-106005 |
| Brand: | MCE |
| CAS: | 1314883-11-8 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 393.38 |
| Molecular Formula | C18H14F3N3O2S |
| SMILES | NC1=NC=C(C2=CC=C(S(=O)(C)=O)C=C2)C=C1C3=CC=C(C(F)(F)F)N=C3 |
1 Publications Citing Use of MCE
Summary
MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (K d app =0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent [1] .
IC50 & Target
|
Plasmodium
|
In Vitro
MMV390048 against intraerythrocytic life cycle stages of P. falciparum (NF54 drug-sensitive strain) showed a steep inhibition curve with IC50 and IC90 values of 28 and 40 nM, respectively.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT02230579 | Medicines for Malaria Venture|University of Cape Town |
Malaria
|
May 2014 | Phase 1 |
| NCT03195387 | Medicines for Malaria Venture|Datamap|PrimeVigilance Zagreb|ICON Clinical Research|Sanaria Inc.|PTx Solutions Ltd., UK|University of Cape Town |
Malaria,Falciparum
|
January 2018 | Phase 1 |
| NCT02783833 | Medicines for Malaria Venture|Clinical Network Services (CNS) Pty Ltd|Q-Pharm Pty Limited|QIMR Berghofer Medical Research Institute |
Malaria
|
May 2016 | Phase 1|Phase 2 |
| NCT02281344 | Medicines for Malaria Venture|Q-Pharm Pty Limited |
Malaria, Falciparum
|
October 2014 | Phase 1 |
| NCT02880241 | Medicines for Malaria Venture|University of Gondar|Jimma University |
Malaria
|
October 20, 2017 | Phase 2 |
| NCT02554799 | Medicines for Malaria Venture|Richmond Pharmacology Limited |
Malaria
|
September 17, 2015 | Phase 1 |
| NCT02783820 | Medicines for Malaria Venture|Clinical Network Services (CNS) Pty Ltd|Q-Pharm Pty Limited|QIMR Berghofer Medical Research Institute |
Malaria
|
May 2016 | Phase 1 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL ( 254.21 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.5421 mL | 12.7104 mL | 25.4207 mL |
| 5 mM | 0.5084 mL | 2.5421 mL | 5.0841 mL |
| 10 mM | 0.2542 mL | 1.2710 mL | 2.5421 mL |
-
1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (6.36 mM); Clear solution
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