[CAS NO. 1315330-11-0] TAK1/MAP4K2inhibitor1
PRODUCTS SPECIFICATIONS [1315330-11-0]
DESCRIPTION [1315330-11-0]
Overview
| MDL | MFCD22572824 |
|---|---|
| Molecular Weight | 552.59 |
| Molecular Formula | C29H31F3N6O2 |
| SMILES | CC(N1)=CC2=C1N=CN=C2OC3=C(C)C=CC(C(NC4=CC=C(CN5CCN(CC)CC5)C(C(F)(F)F)=C4)=O)=C3 |
1 Publications Citing Use of MCE
Summary
TAK1/MAP4K2 inhibitor 1 is a potent dual TGFβ-activated kinase 1 ( TAK1 ) and mitogen-activated protein kinase kinase kinase kinase 2 ( MAP4K2 ) inhibitor, with IC 50 s of 41.1 nM and 18.2 nM, respectively.
IC50 & Target
|
TAK1 41.1 nM (IC 50 ) |
MAP4K2 18.2 nM (IC 50 ) |
In Vivo
TAK1/MAP4K2 inhibitor 1 has moderate terminal elimination half-life (t 1/2 =2.94 h for mice (1 mg/kg, iv)) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 90.48 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.8097 mL | 9.0483 mL | 18.0966 mL |
| 5 mM | 0.3619 mL | 1.8097 mL | 3.6193 mL |
| 10 mM | 0.1810 mL | 0.9048 mL | 1.8097 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.75 mg/mL (4.98 mM); Clear solution