[CAS NO. 132-98-9] Penicillin V Potassium

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PRODUCTS SPECIFICATIONS [132-98-9]

Catalog

HY-B0975

Brand

MCE

CAS

132-98-9

DESCRIPTION [132-98-9]

Overview

MDL	MFCD00051771
Molecular Weight	388.48
Molecular Formula	C16H17KN2O5S
SMILES	O=C(O[K])[C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(COC3=CC=CC=C3)=O)N1C2=O

For research use only. We do not sell to patients.

Summary

Penicillin V Potassium (Phenoxymethylpenicillin potassium salt) is an orally active antibiotic . Penicillin V Potassium inhibits the growth of Streptococci , C. difficile and S. aureus . Penicillin V Potassium can be used for the research of otitis, sinusitis, pharyngitis and tonsillitis ^[1] ^[2] ^[3] ^[4] .

In Vitro

Penicillin V (0.002-8.0 mg/L) inhibits the growth of Streptococci , with the minimum inhibitory concentrations (MICs) of 0.004-0.008 mg/L ^[2] .
Penicillin V (0.002-8.0 mg/L) inhibits the growth of C. difficile , with a MIC ₉₀ of 8 mg/L ^[3] .
Penicillin V (0.004-0.063 mg/L; 18 h) inhibits the growth of Staphylococcus aureus , with a MIC of 0.016 mg/L ^[4] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Penicillin V (0.063-0.25 mg/kg; a single s.c.) inhibits the outgrowth of S. aureus in mice thigh muscle ^[4] .
Penicillin V (100 mg/kg; p.o. once daily for 5 d) avoids the fulminant infection of acute purulent otitis media (AOM) in rats ^[5] .
Penicillin V (2 mg/kg; a single s.c.) exhibits the plasma half-life (61 min) and mean AUC (0.47 mg/L•h) ^[4] ^[4] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Specific pathogen free (SPF) male Swiss mice (20-25 g) are inoculated S. aureus ^[4]
Dosage:	0.063, 0.13, 0.25 mg/kg
Administration:	A single s.c.
Result:	Decreased the number of CFU (1.34×10 ⁷ counts/mL) compared to controls (3.5×10 ⁷ counts/mL) at the dose of 0.25 mg/kg.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT01499875	University of Aarhus\|Aarhus University Hospital Skejby\|Department of Microbiological Surveillance and Research, SSI.	Phenoxymethylpenicillin	January 2012	Phase 1
NCT02922686	Royal College of Surgeons, Ireland\|Health Research Board, Ireland	Cellulitis\|Wound Infection\|Abscess	December 2016	Phase 4
NCT02185209	Margareta Hultin\|Karolinska Institutet	Periodontal Diseases\|Periimplantitis	March 2015	Phase 4
NCT03208361	Jordi Gol i Gurina Foundation	Community-acquired Pneumonia (CAP)	November 5, 2013	Phase 3
NCT01368341	Morten Lindbaek\|Norwegian Institute of Public Health\|Sorlandet Hospital HF\|Norwegian University of Life Sciences\|University of Oslo	Erythema Migrans\|Erythema Chronicum Migrans\|Borreliosis\|Lyme Disease\|Early Lyme Disease	June 2011	Phase 4
NCT02188472	Henrik Enghusen Poulsen\|Klinisk Biokemisk Afdeling\|Klinisk farmakologisk Afdeling\|Sektion for Biomedicin Institut for Veterinær Patobiologi\|Rigshospitalet, Denmark	Oxidative Stress	November 2010	Phase 1
NCT04084106	Uppsala University	Infectious Disease	September 10, 2019	Phase 4
NCT00823433	William Beaumont Hospitals	Group B Streptococcus	January 2009	Early Phase 1
NCT04083417	Katarina Hedin\|Umeå University\|Linkoeping University\|Lund University\|Region Jönköping County	Sore Throat\|Tonsillitis	September 9, 2019	Phase 4
NCT03326661	Odense University Hospital	Peritonsillar Abscess	November 10, 2017	Not Applicable
NCT02712307	Ass. Prof. Katarina Hedin\|Public Health Agency of Sweden	Tonsillitis	September 2015	Phase 4

Appearance

Solid

Source

strains of Penicillium chrysogenum

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 12 mg/mL ( 30.89 mM ; Need ultrasonic)

H ₂ O : 6 mg/mL ( 15.44 mM ; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5741 mL	12.8707 mL	25.7414 mL
5 mM	0.5148 mL	2.5741 mL	5.1483 mL
10 mM	0.2574 mL	1.2871 mL	2.5741 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: PBS

Solubility: 100 mg/mL (257.41 mM); Clear solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 1.2 mg/mL (3.09 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1.2 mg/mL (3.09 mM); Clear solution
4.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1.2 mg/mL (3.09 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-, potassium salt (1:1), (2S,5R,6R)-

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)-, monopotassium salt

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-, monopotassium salt, [2S-(2α,5α,6β)]-

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-, monopotassium salt, (2S,5R,6R)-

V-Cillin K

Compocillin VK

Penicillin V potassium

Pen-Vee-K

Pen-Vee K Powder

Penvikal

Phenoxymethylpenicillin potassium

Potassium penicillin V

Potassium penicillin V salt

Potassium phenoxymethylpenicillin

Isocillin

Penicillin V potassium salt

Stabillin VK syrup 62.5

Stabillin VK syrup 125

Phenoxymethylpenicillin potassium salt

Potassium 2,2-dimethyl-6β-phenoxyacetamidopenam-3α-carboxylate

Potassium phenoxymethylpenicillinate

Cliacil

Beromycin

Beromycin (penicillin)

Roscopenin

Fenoxypen

Kavepenin

Penicillin VK

Primcillin

Megacillin-oral

Fenocin

V-Pen

Uticillin Vk

Suspen

Anapenil

Penadur VK Mega

Fenoxcillin

Apsin VK

V-Penicillin Kalium

Newcillin

Trepopen VK

Pen-Vi-K

Milcopen

Robicillin VK

Abbocillin VK

Megacilina Oral

Apo-Pen VK

DuraPenicillin

Pfizerpen Vk

Pentabs

Novopen VK

Beepen Vk

Acipen

Rafapen V-K

Stabilin V-K

Orvek

Penivoral

Betapen Vk

Len VK

Cilicaine VK

Nadopen V

Vepicombin

Trepopen

V-Kal K

V-Cil K

Penoxilin

Pen-V

Distaquaine V-K

Oracillin VK

Ospen KV

Servipen V

Pentacillin

Veetids

L.P.V.

Pentranex

Ispenoral

Arcasin

Novo VK

Ospen 250

Vamosyn

Microcillin VK

Micropen VK

Cilacil

Penvisil

Beapen

Asillin

Rocilin

P.V.O.

PVK

Fenospen

Ledercillin Vk

Monocillin E

Betapen V

Vepen

Ocillin VK

Beromycin 400

Calciopen K

Distakaps V-K

Ospeneff

Pedipen

Dowpen V-K

SK-Penicillin VK

Pen V-K

Antibiocin

Fenocin Forte

Pencompren

Qidpen VK

Orapen

DQV-K

Rocillin VK

Oracil VK

Penapar VK

Icipen

Penagen

Sumapen VK

Arcacil

Penicillin V Potassium