[CAS NO. 133053-19-7] Go6983

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PRODUCTS SPECIFICATIONS [133053-19-7]

Catalog

HY-13689

Brand

MCE

CAS

133053-19-7

DESCRIPTION [133053-19-7]

Overview

MDL	MFCD04040031
Molecular Weight	442.51
Molecular Formula	C26H26N4O3
SMILES	O=C(C(C1=CN(CCCN(C)C)C2=C1C=C(OC)C=C2)=C3C4=CNC5=C4C=CC=C5)NC3=O

For research use only. We do not sell to patients.

38 Publications Citing Use of MCE

Summary

Go 6983 is a pan-PKC inhibitor against for PKCα , PKCβ , PKCγ , PKCδ and PKCζ with IC ₅₀ of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.

IC50 & Target

PKCγ

6 nM (IC ₅₀ )

PKCα

7 nM (IC ₅₀ )

PKCβ

7 nM (IC ₅₀ )

PKCδ

10 nM (IC ₅₀ )

PKCζ

60 nM (IC ₅₀ )

PKCμ

20000 nM (IC ₅₀ )

In Vitro

Go 6983 inhibits PKCμ with IC ₅₀ of 20 μM, and the pther PKC isoenzymes can be suppressed by Go 6983 with IC ₅₀ values from 7 to 60 nM ^[1] . Go 6983 (100 nM) significantly reduces PMN adherence to the endothelium and infiltration into the myocardium compared with I/R + PMN hearts, and significantly inhibits superoxide release from PMNs by 90 +/- 2% in rat hearts ^[2] . Go 6983 (200 nM) has a reduced cardioprotective effect compared with the cardioprotective Go 6983 concentrations (50 and 100 nM) despite inhibiting PMN superoxide release by 99% ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 34 mg/mL ( 76.83 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2598 mL	11.2992 mL	22.5984 mL
5 mM	0.4520 mL	2.2598 mL	4.5197 mL
10 mM	0.2260 mL	1.1299 mL	2.2598 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (5.65 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (5.65 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: 2.5 mg/mL (5.65 mM); Suspended solution; Need ultrasonic

* All of the co-solvents are available by MCE.