[CAS NO. 1334294-76-6] GSK682753A
PRODUCTS SPECIFICATIONS [1334294-76-6]
DESCRIPTION [1334294-76-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 479.78 |
| Molecular Formula | C23H21Cl3N2O3 |
| SMILES | O=C1OC2(CCN(C(/C=C/C3=CC=C(Cl)C=C3)=O)CC2)CN1CC4=CC=C(Cl)C(Cl)=C4 |
2 Publications Citing Use of MCE
Summary
GSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 ( EBI2 ) with an IC 50 of 53.6 nM.
IC50 & Target
IC50: 53.6 nM (EBI2) [1]
In Vitro
GSK682753 is a selective and highly potent inverse agonist for murine as well as human EBI2 with inhibition of G protein-dependent signals as well as signals that are probably G protein-independent. In cAMP-response element-binding protein-based reporter and guanosine5'-3-O-(thio)-triphosphate (GTPγS) binding assays, the potency of this compound is 2.6-53.6 nM, and its inhibitory efficacy is 75%. GSK682753A dose-dependently inhibits EBI2 with an IC 50 of 53.6 nM. GSK682753A inhibits ERK phosphorylation, GTPγS binding, and cAMP-response element-binding protein activation with similar potency [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 208.43 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.0843 mL | 10.4214 mL | 20.8429 mL |
| 5 mM | 0.4169 mL | 2.0843 mL | 4.1686 mL |
| 10 mM | 0.2084 mL | 1.0421 mL | 2.0843 mL |