- Cart - 0 item(s)
- $0.00
Your shopping cart is empty!
- Chemistry
- Bioactive Molecules
- Anti-infection
- Apoptosis
- Autophagy
- Cell Cycle/DNA Damage
- Cytoskeleton
- Epigenetics
- GPCR/G Protein
- Immunology/Inflammation
- JAK/STAT Signaling
- MAPK/ERK Pathway
- Membrane Transporter/Ion Channel
- Metabolic Enzyme/Protease
- Neuronal Signaling
- NF-κB
- PI3K/Akt/mTOR
- PROTAC
- Protein Tyrosine Kinase/RTK
- Stem Cell/Wnt
- TGF-beta/Smad
- Vitamin D Related/Nuclear Receptor
- Others
- Methylation
- Cytoskeletal Signaling
- Natural Products
- Alkaloids
- Amino acid
- Anthraquinones
- Cerebrosides
- Chalcones
- Coumarins
- Diterpenoids
- Flavonoids
- Iridoids
- Lignans
- Lipids
- Miscellaneous
- Monoterpenoids
- Other terpenes
- Phenols
- Phenylpropanoids
- Quinones
- Saccharides
- Sesquiterpenoids
- Steroids
- Tetraterpenoids
- Thiophenes
- Triterpenoids
- Xanthones
- Polyphenols
- Stibene glucosides
- Oligose
- Anthocyanins
- Miscellaneous
- Chromones
- Terpenoids
- Indoles
- Procyanidins
- Aliphatics
- Botanical Cyclopeptides
- ADCs
- Antibodies
- Multiplex IHC
- Material Science
- Others
[CAS NO. 133876-92-3] Nattokinase, Natto fermentation
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-P2373 |
| Brand: | MCE |
| CAS: | 133876-92-3 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | - |
| Molecular Formula | - |
| SMILES | - |
Summary
Nattokinase is a potent fibrinolytic enzyme. Nattokinase can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Nattokinase can be used for the research of cardiovascular diseases [1] .
In Vitro
Nattokinase dissolves 94% blood clot at ten minutes and degrades the fibrin clot after two hours of incubation [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Nattokinase (150-250 mg/kg; oral gavage twice daily for 2 days) exhibits fibrinolytic activity and dissolves blood clots in vivo [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Sprague-Dawley (SD) rats (180-220 g) are injected κ-Carrageenan [3] |
| Dosage: | 150, 250 mg/kg |
| Administration: | Oral gavage twice daily for 2 days |
| Result: |
Increased the plasma concentration of fibrin/fibrinogen degradation products (FDPs) and D-Dimer in a dose-dependent manner.
Decreased the fraction of the vessel cross section occupied by thrombosis. |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT02886507 | Natural Immune Systems Inc|JBSL-USA Incorporated |
Hypertension
|
March 2012 | Phase 4 |
| NCT00749801 | Chi Mei Medical Hospital|GeneFerm Biotechnology Co., Ltd. |
Hyperlipidemia
|
May 2007 | Not Applicable |
| NCT02913170 | Yonsei University |
Hypercholesterolemia
|
May 2015 | Phase 4 |
| NCT00447434 | Changhua Christian Hospital |
Thrombosis|Cardiovascular Diseases
|
June 2005 | Phase 4 |
| NCT02080520 | University of Southern California |
Prevention of Subclinical Atherosclerosis Progression|Prevention of Cognitive Decline
|
April 2014 | Phase 2 |
| NCT05200234 | Second Affiliated Hospital, School of Medicine, Zhejiang University |
Cerebral Blood Flow|Cognitive Function
|
January 13, 2022 | Not Applicable |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Sealed storage, away from moisture
| Powder | -80°C | 2 years |
|---|---|---|
| -20°C | 1 year |
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 100 mg/mL (Need ultrasonic)
-
1.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (Infinity mM); Clear solution; Need ultrasonic
References
- [1] Weng Y, et, al. Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease. Int J Mol Sci. 2017 Feb 28; 18(3):523.
- [2] Chandrasekaran SD, et, al. Exploring the In Vitro Thrombolytic Activity of Nattokinase From a New Strain Pseudomonas aeruginosa CMSS. Jundishapur J Microbiol. 2015 Oct 26; 8(10): e23567.
- [3] Xu J, et, al. Thrombolytic effects in vivo of nattokinase in a carrageenan-induced rat model of thrombosis. Acta Haematol. 2014; 132(2): 247-53.
Arctom is a premier supply platform offering over 600K unique items of Building Blocks, Bioactive Molecules, Natural Products, ADC PEG Linkers, Antibodies, and other Research Chemicals for global pharmaceutical, biotech, university, and industrial customers. We accelerate your research by providing better and faster purchasing experience & services.