[CAS NO. 13476-25-0] Linderane

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PRODUCTS SPECIFICATIONS [13476-25-0]

Catalog

HY-N0688

Brand

MCE

CAS

13476-25-0

DESCRIPTION [13476-25-0]

Overview

MDL	-
Molecular Weight	260.29
Molecular Formula	C15H16O4
SMILES	O=C(O[C@@]1([H])C2=C3OC=C2C)C4(CC/C=C(C)\C3)[C@@H]1O4

For research use only. We do not sell to patients.

Summary

Linderane, isolated from the root of Lindera aggregata , is an irreversible inhibitor cytochrome P450 2C9 (CYP2C9) . Linderane has the potential to relieve pain and cramp ^[1] .

IC50 & Target

CYP2

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 384.19 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8419 mL	19.2093 mL	38.4187 mL
5 mM	0.7684 mL	3.8419 mL	7.6837 mL
10 mM	0.3842 mL	1.9209 mL	3.8419 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (9.60 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Wang H, et al. Mechanism-based inactivation of CYP2C9 by linderane. Xenobiotica. 2015;45(12):1037-46.

Synonyms

2H-10,1a-(Epoxymethano)oxireno[4,5]cyclodeca[1,2-b]furan-12-one, 3,6,10,10a-tetrahydro-5,9-dimethyl-, (1aS,4E,10S,10aS)-

4βH-Germacra-1(10),7,11-trien-15-oic acid, 4,5β:8,12-diepoxy-6α-hydroxy-, γ-lactone, (E)-

2H-10,1a-(Epoxymethano)oxireno[4,5]cyclodeca[1,2-b]furan-12-one, 3,6,10,10a-tetrahydro-5,9-dimethyl-, [1aS-(1aR*,4E,10R*,10aR*)]-

Linderane

(1aS,4E,10S,10aS)-3,6,10,10a-Tetrahydro-5,9-dimethyl-2H-10,1a-(epoxymethano)oxireno[4,5]cyclodeca[1,2-b]furan-12-one