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Catalog: | HY-108015 |
Brand: | MCE |
CAS: | 1357266-05-7 |
MDL | - |
---|---|
Molecular Weight | 194.21 |
Molecular Formula | C10H11FN2O |
SMILES | CC1=C([C@@H]2N=C(N)OC2)C=CC=C1F |
RO5263397 (0.1-1.0 mg/kg; p.o.; dosing at the mid-light phase (ZT6)) increased wake time at 0.3 and 1 mg/kg
[2]
.
RO5263397 (0.3 and 1.0 mg/kg; p.o.) decreases NREM time in WT mice. RO5263397 (0.3 and 1.0 mg/kg; p.o.; in OE mice) powerfully increases W time in OE mice for 5-6 h. NREM sleep is suppressed for 4-6 h and REM sleep is almost completely suppressed for 6 h after all doses of RO5263397
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model: | Adult 4-5-month-old male WT littermates (C57BL/6 background) [2] |
Dosage: | 0.1, 0.3, 1 mg/kg |
Administration: | p.o.; dosing at the mid-light phase (ZT6) |
Result: | Increased wake time at 0.3 and 1 mg/kg |
Solid
Room temperature in continental US; may vary elsewhere.
Powder | -20°C | 3 years |
---|---|---|
4°C | 2 years | |
In solvent | -80°C | 6 months |
-20°C | 1 month |
DMSO : 260 mg/mL ( 1338.76 mM ; Need ultrasonic)
Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
---|
1 mM | 5.1491 mL | 25.7453 mL | 51.4907 mL |
5 mM | 1.0298 mL | 5.1491 mL | 10.2981 mL |
10 mM | 0.5149 mL | 2.5745 mL | 5.1491 mL |
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