[CAS NO. 1360614-48-7] Necrosulfonamide

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PRODUCTS SPECIFICATIONS [1360614-48-7]

Catalog

HY-100573

Brand

MCE

CAS

1360614-48-7

DESCRIPTION [1360614-48-7]

Overview

MDL	MFCD02370191
Molecular Weight	461.47
Molecular Formula	C18H15N5O6S2
SMILES	O=C(NC1=CC=C(S(=O)(NC2=NC=CN=C2OC)=O)C=C1)/C=C/C3=CC=C([N+]([O-])=O)S3.[(E)]

For research use only. We do not sell to patients.

44 Publications Citing Use of MCE

Summary

Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL) . Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. MLKL is a critical substrate of RIP3 during the induction of necrosis ^[1] .

In Vitro

Necrosulfonamide specifically blocks necrosis downstream of RIP3 activation. Necrosulfonamide inhibits MLKL-mediated necrosis by blocking Its N-terminal CC domain function ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 28 mg/mL ( 60.68 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1670 mL	10.8349 mL	21.6699 mL
5 mM	0.4334 mL	2.1670 mL	4.3340 mL
10 mM	0.2167 mL	1.0835 mL	2.1670 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 50% PEG300 >> 50% saline

Solubility: 10 mg/mL (21.67 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 20% SBE-β-CD in saline

Solubility: 6.67 mg/mL (14.45 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.5 mg/mL (5.42 mM); Suspended solution; Need ultrasonic
4.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (5.42 mM); Suspended solution; Need ultrasonic
5.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: 2.5 mg/mL (5.42 mM); Suspended solution; Need ultrasonic

* All of the co-solvents are available by MCE.

References

[1] Sun L, et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell. 2012;148(1-2):213-227.